Improving the efficiency of CRISPR gene editing in cells

人红细胞的特征很清楚，珠蛋白基因座是研究基因调控的模型系统。基因编辑技术和递送工具正在迅速发展，珠蛋白基因座是基因编辑优化的完美模型。悉尼新南威尔士大学和CSL之间的合作旨在将我们的专业知识和新技术结合起来，为红细胞系的遗传修饰开发一个最佳平台。同时，该项目旨在对人类基因调控机制产生基本见解。该项目的技术和生物学成果将有利于未来的基因编辑应用。

Human red blood cells are well-characterised and the globin gene locus is a model system for the study of gene regulation. Gene editing technologies and delivery tools are evolving rapidly and the globin gene locus is the perfect model for gene editing optimisation. This collaboration between UNSW Sydney and CSL aims to bring together our combined expertise and new technologies to develop an optimal platform for genetic modification in a red blood cell line. Simultaneously, this project aims to generate fundamental insights into mechanisms of human gene regulation. The technological and biological outcomes of this project will be of benefit for future gene editing applications.