Development of self-mixing type laser Doppler frowmetry

自混合式激光多普勒流量计的研制

• 批准号: 04557117
• 负责人: MITO Keiichiro
• 金额: $ 0.83万
• 依托单位: Kawasaki College of Allied Health
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Developmental Scientific Research (B)
• 财政年份: 1992
• 资助国家: 日本
• 起止时间: 1992 至 1993
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-04557117/
• 关键词: Self-mixing effect; Doppler signal; Semiconductor laser diode; Near infra-red; Tissue blood flow; Multiple scattering; Photoimmunotherapy; Cancer treatment

We investigated the characteristics of a self-mixed Doppler signal obtained from multiple moving targets with different velocity components theoretically and experimentally for the measurement of blood flow in tissue. The results showed that the self-mixed Doppler signal was linearly superimposed from each waveform of the different frequency components obtained from the multiple moving targets. The maximum frequency (Fmax) of the superimposed spectrum was estimated to be about 70% of the peak flow velocity of the multiple moving targets with different velocities. This value provides tentative criteria for judgment of tissue blood flow. Excellent linear relationships were obtained between the frequency (Fmax) of the blood velocity and the known blood flow velocity in the flow channel (0.994).

本文从理论和实验两方面研究了用于组织内血流测量的多个运动目标的自混合多普勒信号的特性。结果表明，自混合多普勒信号是由多个运动目标获得的不同频率分量的波形线性叠加而成。叠加频谱的最大频率（Fmax）估计为具有不同速度的多个运动目标的峰值流速的70%左右。该值为判断组织血流提供了初步标准。在血流速度的频率（Fmax）和已知的血流通道中的血流速度（0.994）之间获得了良好的线性关系。

项目成果

K.Mito: "Characteristics of laser Doppler flowmetry which is the different optical arrangement." Medical Engineering & Technology. 16-6. 236-242 (1992)

K.Mito：“激光多普勒血流测量的特点是不同的光学布置。”

K.Mito et al.: "Characteristics of local blood flow in the cancer graf to with difference of proliferative pattern in the nucle mice" Biorheolegy. 29. 58 (1992)

K.Mito 等人：“肿瘤移植物中局部血流的特征与核小鼠增殖模式的差异”生物流变学。

K.Mito: "Charactertics of Laser Doppler Howmetry whidis to Different of ticalmogment" Medical Engineering & Techuology. 16. 236-242 (1992)

K.Mito：“激光多普勒测温的特点对不同运动的影响”医学工程

Keiichiro Mito et al.: "Solf-mixing effect of the semiconductor laser Doppler method for blood flow masurement" Medical & Biological Engineering & Computing. 31. (1993)

Keiichiro Mito 等人：“用于血流测量的半导体激光多普勒方法的自溶混合效应”医学

K.Mito: "Characteristics of laser Doppler flowmetry which is the different optical arrangement" Medical Engineeriny & Technology. 16. 236-242 (1992)

K.Mito：“激光多普勒血流计的特点，即不同的光学排列” 医学工程