Study on fetal circulation using Doppler signal and pulse waveforms

利用多普勒信号和脉搏波形研究胎儿循环

• 批准号: 12671609
• 负责人: NAKANO Hitoo
• 金额: $ 2.24万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12671609/
• 关键词: human fetus; descending aorta; pulse waveform; cardiac function; pulse pressure; isovolumetric contraction time; placental insufficiency; cardiocirculatory failure; ドプラ超音波; 胎児心機能; 収縮時相解析; ドプラ超音波法; 胎児収縮時相

(1) Study on fetal isovolumetric contraction time: To study the fetal cardiac isovolumetric contraction time (ICT) in normal and complicated pregnancies with placental vascular disease, ICTs were measured in 160 normal fetuses and 55 complicated pregnancies. In normal pregnancy, the ICT remained constant with gestation and fetal heart rate. A strong correlation between prolonged ICT duration and abnormalities in the perinatal course, indicating that a prolonged fetal ICT predicts adverse outcome in the presence of placental vascular disease.(2) Study on fetal pulse waveform in the descending aorta: Pulse waveforms of the fetal descending aorta were obtained using an echo-tracking system to clarify the gestational age-related changes and the usefulness for detecting cardiac dysfunction. Peak-systolic (PSD) and end-diastolic diameter (EDD), pulse amplitude (Amp) and Amp:EDD ratio, calculated from the pulse waveforms, were adopted for analysis. In 196 normal fetuses after 20 weeks, the PSD, EDD and Amp increased, and Amp:EDD ratio decreased linearly with advancing gestation. The 19 fetuses with suspected cardiac dysfunction were divided into healthy and altered cardiac function subgroups, according to the values of fractional shortening and preload index. Of these, 7 fetuses with cardiac dysfunction had significantly higher incidence of low Amp (p<0.01) and Amp:EDD ratio (p<0.001) than remaining 12 fetuses with normal cardiac function. The pulse waveform analysis in the fetal descending aorta proved useful for detecting fetal cardiac dysfunction in utero.

(1)胎儿等容收缩时间的研究：对160例正常胎儿和55例合并胎盘血管疾病孕妇的胎儿心脏等容收缩时间(ICT)进行测量，以探讨其在正常妊娠和合并胎盘血管疾病妊娠中的意义。在正常妊娠中，ICT随妊娠和胎心率的变化不变。ICT持续时间延长与围产期异常之间存在很强的相关性，表明胎儿ICT延长预示着胎盘血管疾病的不良结局。(2)降主动脉胎儿脉搏波形的研究：使用回声跟踪系统获得胎儿降主动脉的脉搏波形，以阐明与胎龄相关的变化及其对检测心脏功能障碍的作用。采用脉搏波计算的收缩末期内径(PSD)、舒张末内径(EDD)、脉搏幅度(Amp)及Amp/EDD比值进行分析。196例正常胎儿胎龄20周后，PSD、EDD、AMP值随孕龄增加而增加，AMP/EDD值呈线性下降。根据短轴缩短率和前负荷指数的大小，将19例可疑心功能不全的胎儿分为心功能正常组和心功能异常组。其中7例心功能不全胎儿的低AMP发生率(P&lt；0.01)和AMP/EDD比值(P&lt；0.001)显著高于其余12例心功能正常的胎儿。胎儿降主动脉脉搏波分析有助于宫内胎儿心功能不全的检测。

项目成果

Satoh S, et al.: "Antenatal sonographic detection of vesicoureteral reflux : A case report"Fetal Diagnosis and Therapy. 17. 277-280 (2002)

Satoh S 等人：“膀胱输尿管反流的产前超声检测：病例报告”胎儿诊断和治疗。

Y. Fujita S. Satoh, T. Koga, A. Mori, H. Nakano: "Aortic pulse waveforms for evaluating cardiac performance in the human fetus"Ultrasound in Medicine and Biology. 28. 1245-1250 (2002)

Y. Fujita S. Satoh、T. Koga、A. Mori、H. Nakano：“用于评估人类胎儿心脏性能的主动脉脉冲波形”医学和生物学中的超声。

Satoh S, Inatomi S, Kubota M, Suita S, Nakano M: "Antenatal sonographic detection of vesicoureteral reflux: A case report"Fetal Diagnosis and Therapy. 17. 277-280 (2002)

Satoh S、Inatomi S、Kubota M、Suita S、Nakano M：“膀胱输尿管反流的产前超声检测：病例报告”胎儿诊断与治疗。

Koga T, Athayde H, Trudinger B, Nakano H: "A new and simple Doppler method for measurement of fetal cardiac isovolumetric contraction time"Ultrasound in Obstetrics and Gynecology. 18. 264-267 (2001)

Koga T、Athayde H、Trudinger B、Nakano H：“一种新的、简单的多普勒测量胎儿心脏等容收缩时间的方法”妇产科超声。

Koga T, et al.: "A new and simple Doppler method for measurement of fetal cardiac isovolumetric contraction time"Ultrasound in Obstertrics and Gynecology. 18. 264-267 (2001)

Koga T 等人：“一种新的、简单的多普勒方法，用于测量胎儿心脏等容收缩时间”妇产科超声。