Study on Total Synthesis of Anti-tumorous Varacin and Application to Anti-tumor Drag

近年来，环多硫化物的特殊化学性质引起了有机硫化学领域的广泛关注。我们还报道了苯并戊硫平及其相关化合物的新合成方法。此外，我们还发现了许多由这种环状多硫化物生成杂环的反应。在这些发现的基础上，我们的兴趣转向了合成新的生物活性苯并戊硫平，例如瓦拉星和lissoclinotoxins，它们在海洋天然产物中被发现，最近已报道了总合成。现在，我们希望报道两种新型的苯并喷妥霉素，6,7，-二甲氧基苯并喷妥霉素和6-氨基乙基苯并喷妥霉素，这是瓦拉星的部分结构，使用我们的原始方法，在单质硫和气态氨中高效合成和生物学性质。

Recently, the characteristic chemical properties of cyclic polysulfides have attracted wide attention in the field of organosulfur chemistry. We have also reported new methods for the synthesis of benzopentathiepins and the related compounds. Furthermore, we have found many reactions for providing some heterocycles from such cyclic polysulfides. On the basis of these findings, our interests were directed to the synthesis of novel biologically active benzopentathiepin, for example, varacin and lissoclinotoxins, which were found in marine natural products and the total syntheses have been recently reported. Now, we wish to report an efficient synthesis and the biological properties of two novel benzopentathiepins, 6,7, -dimethoxybenzopentathiepin and 6-aminoethylbenzopentathiepin, which are partial structures of varacin, using our original method with elemental sulfur and gaseous ammonia.