Catalytic C-C bond forming hydrogenation for synthesis of anti-tumor natural prod

描述(由申请人提供)：拟议资助期的主要目标是培训David Del Valle先生，使他在国家最高一级的有机化学领域具有竞争力。对于合成有机化学家来说，最重要的培训基础是全合成。开始这样的努力可以发展合成复杂分子所需的技能。这些技能包括合成计划、反应优化和结果解释中涉及的问题解决技能。他将通过致力于安沙霉素类抗肿瘤抗生素的全合成来发展和提高他在这些领域的能力。这项研究项目将提高他的独立思考能力、数据和结果的解释能力、科学数据的表达能力和有机化学的技术技能。两年的资金应该足以让大卫接受研究生水平的培训。他将是唯一在资助机会下接受培训的学生，Krische小组中将有大约20名学生与他互动。 与公共健康相关：这一研究培训计划将提供开始研究癌症新的潜在治疗方法所需的基础化学研究。该项目还将培训一名科学家如何制造对公共健康产生积极影响的新药。

DESCRIPTION (provided by applicant): The primary goal of the proposed funding period resides in the training of Mr. David Del Valle, such that he becomes competitive in the field of organic chemistry at the highest national level. The paramount training ground for a synthetic organic chemist is through total synthesis. Embarking on such an endeavor allows for the development of skills needed to synthesize complex molecules. These include the problem solving skills involved in synthesis planning, reaction optimization and the interpretation of results. He will develop in improve his abilities in these areas by working on the total synthesis of the ansamycin class of antitumor antibiotics. This research project will improve his abilities for independent thinking, interpretation of data and results, presentation of scientific data, and technical skill in organic chemistry. Two years of funding should be enough for David to train at the graduate student level. He will be the only student trained under the funding opportunity, and there will be about 20 students in the Krische group that he will interact with. PUBLIC HEALTH RELEVANCE: This research-training program will provide the basic chemistry research needed to begin investigating a new potential treatment for cancer. The program will also train a scientist how to make new medicines that will have a positive impact on public health.