Catalytic C-C bond forming hydrogenation for synthesis of anti-tumor natural prod

催化C-C键形成氢化合成抗肿瘤天然产物

• 批准号: 8332377
• 负责人: David J. Del Valle
• 金额: $ 1.8万
• 依托单位: UNIVERSITY OF TEXAS AT AUSTIN
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-24 至 2013-05-23
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8332377
• 关键词: Alcohols; Aldehydes; Area; Biological Factors; Cells; Chemistry; Complex; Coupling; Data; Development; FDA approved; Funding; Funding Opportunities; Generations; Goals; Hydrogenation; Investigation; Medicine; Metals; Methods; Organic Chemistry; Oxidation-Reduction; Problem Solving; Process; Public Health; Reaction; Reagent; Reporting; Research; Research Project Grants; Research Training; Rifabutin; Sampling; Scheme; Scientist; Students; Testing; Therapeutic Agents; Thinking; Time; Training; Training Programs; Work; antineoplastic antibiotics; cancer therapy; graduate student; improved; member; oxidation; programs; skills; tumor

DESCRIPTION (provided by applicant): The primary goal of the proposed funding period resides in the training of Mr. David Del Valle, such that he becomes competitive in the field of organic chemistry at the highest national level. The paramount training ground for a synthetic organic chemist is through total synthesis. Embarking on such an endeavor allows for the development of skills needed to synthesize complex molecules. These include the problem solving skills involved in synthesis planning, reaction optimization and the interpretation of results. He will develop in improve his abilities in these areas by working on the total synthesis of the ansamycin class of antitumor antibiotics. This research project will improve his abilities for independent thinking, interpretation of data and results, presentation of scientific data, and technical skill in organic chemistry. Two years of funding should be enough for David to train at the graduate student level. He will be the only student trained under the funding opportunity, and there will be about 20 students in the Krische group that he will interact with.

描述（由申请人提供）：拟议资助期的主要目标在于培训大卫德尔瓦莱先生，使他在国家最高水平的有机化学领域具有竞争力。合成有机化学家最重要的训练基础是通过全合成。从事这样的奋进可以发展合成复杂分子所需的技能。这些包括合成规划，反应优化和结果解释中涉及的问题解决技能。他将通过研究抗肿瘤抗生素安莎霉素类的全合成来提高他在这些领域的能力。这个研究项目将提高他的独立思考能力，数据和结果的解释能力，科学数据的表达能力，以及有机化学的技术技能。两年的资金应该足以让大卫进行研究生水平的培训。他将是唯一一个在资助机会下接受培训的学生，Krische小组中将有大约20名学生与他互动。