Newlly Development and a Clinical Application of a Novel Preservation Solution for the lung (ET-Kyoto Solution)

肺移植已被确定为终末期肺部疾病患者的成功治疗选择。然而，由于缺乏合适的供体肺，这种手术的广泛应用受到限制。为了克服这一限制，我们开发了一种新的细胞外或细胞内型溶液，ET-Kyoto或IT-Kyoto溶液，其中含有4.1%的海藻糖、葡萄糖酸盐和羟乙基淀粉（HES）。我们的研究结果表明，ET-Kyoto溶液保存移植肺20小时的功能明显优于IT-Kyoto或Euro-Collins溶液。我们的研究结果还表明，ET-Kyoto溶液保存30小时的移植肺功能明显优于University of Wisconsin溶液。在本报告中，明确地证明了ET-K溶液是一种始终如一的优良防腐溶液。希望本研究的结果将有助于增加供肺的供应，使临床肺移植领域的半选择性手术成为可能。

Lung transplantation has been established as a successful therapeutic option for patients with end-stage lung diseases. However, the the wide spread application of this proedure is limited by the shortage of suitable donor lungs. To oversome this limitation, we developed a new extra or intracellular type solution, ET-Kyoto or IT-Kyoto solution, which contains 4.1% trehalose, gluconate, and hydroxyethyl starch (HES). Our results demonstrated that the function of the transplanted lung preserved with the ET-Kyoto solution for 20 hours was significantly better than those of lungs with IT-Kyoto or Euro-Collins solution. Our results also showed that the function of the transplanted lung preserved with the ET-Kyoto solution for 30 hours was significantly better than that of lungs with the University of Wisconsin solution. In this report, it was demonstrated definitely that the ET-K solution is a consistently excellent preservative solution. It is hoped that the result of this study will contribute to an increase in the supply of donor lungs and make semielective operations possible in the field of clinical lung transplantation.