Newlly Development and a Clinical Application of a Novel Preservation Solution for the lung (ET-Kyoto Solution)

新型肺保存液（ET-Kyoto Solution）的最新研制及临床应用

• 批准号: 05557064
• 负责人: WADA Hiromi
• 金额: $ 10.88万
• 依托单位: KYOTO UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Developmental Scientific Research (B)
• 财政年份: 1993
• 资助国家: 日本
• 起止时间: 1993 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-05557064/
• 关键词: Trehalose; Lung preservation; Lung transplantation; Extracellular type solution; ET-Kyoto solution; IT-Kyoto solution; University of Wisconsin solution; 臓器保存液

Lung transplantation has been established as a successful therapeutic option for patients with end-stage lung diseases. However, the the wide spread application of this proedure is limited by the shortage of suitable donor lungs. To oversome this limitation, we developed a new extra or intracellular type solution, ET-Kyoto or IT-Kyoto solution, which contains 4.1% trehalose, gluconate, and hydroxyethyl starch (HES). Our results demonstrated that the function of the transplanted lung preserved with the ET-Kyoto solution for 20 hours was significantly better than those of lungs with IT-Kyoto or Euro-Collins solution. Our results also showed that the function of the transplanted lung preserved with the ET-Kyoto solution for 30 hours was significantly better than that of lungs with the University of Wisconsin solution. In this report, it was demonstrated definitely that the ET-K solution is a consistently excellent preservative solution. It is hoped that the result of this study will contribute to an increase in the supply of donor lungs and make semielective operations possible in the field of clinical lung transplantation.

肺移植已被确立为终末期肺部疾病患者的成功治疗选择。然而，由于缺乏合适的供体肺，限制了这种方法的广泛应用。为了克服这一限制，我们开发了一种新的细胞外或细胞内型溶液，ET-Kyoto或IT-Kyoto溶液，其含有4.1%的海藻糖、葡萄糖酸盐和羟乙基淀粉（HES）。我们的结果表明，用ET-Kyoto液保存20小时的移植肺的功能明显优于用IT-Kyoto或Euro-Collins液保存的肺。我们的研究结果还表明，用ET-京都溶液保存30小时的移植肺的功能明显优于用威斯康星州大学溶液保存的肺。在本报告中，明确证明ET-K溶液是一种一贯优良的防腐剂溶液。希望本研究的结果有助于增加供肺的供应，使临床肺移植领域的半选择性手术成为可能。

项目成果

Bando, T., Kosaka, S., Liu, C.J., Hirai, T., Hirata, T., Yokomise, H., Yagi, K., Inui, K., Hitomi, H., Wada, H.: "Effect of newly developed solutions containing trehalose on 20-hour canine lung preservation." J Thoracic Cardiovascular Surgery. 108. 92-98

Bando, T.、Kosaka, S.、Liu, C.J.、Hirai, T.、Hirata, T.、Yokomise, H.、Yagi, K.、Inui, K.、Hitomi, H.、Wada, H.：“

Fukuse, T., Hirata, T., Yokomise, H., Inui, K., Hitomi, S., Mitsui, A., Hirakawa, T., Yodoi, J., Wada, H.: "Attenuation of ischaemia-reperfusion injury by human thioredoxin." Thorax. 50. 387-391 (1995)

Fukuse，T.，Hirata，T.，Yokomise，H.，Inui，K.，Hitomi，S.，Mitsui，A.，Hirakawa，T.，Yodoi，J.，Wada，H.：“缺血的衰减-

Liu. C. J.: "Improved 20-hour Canine Lung Preservation With a New Solution-ET-Kyoto Solution." European Journal of Cardio-thorac cSurgery.9. 548-552 (1995)

刘.

Wada, H.: "Newly developed preservation solution for the lung 30-hour preservation with new ET-Kyoto solution" Transplantation Proceeding.(1995)

Wada, H.：“新开发的肺保存液，使用新的 ET-Kyoto 溶液保存 30 小时”移植论文集。（1995 年）

Bando Toru: "Effect of newly developed solutions containing trehalose on 20-hour canine lung preservation." J Thoracic Cardiovascular Surgery.108. 92-98 (1994)

Bando Toru：“新开发的含有海藻糖的溶液对 20 小时犬肺保存的影响。”