Neurobehavioral effects of hypothyroidism on the next generation in the rat

甲状腺功能减退症对大鼠下一代神经行为的影响

• 批准号: 17590531
• 负责人: WADA Hiromi
• 金额: $ 1.73万
• 依托单位: HOKKAIDO UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17590531/
• 关键词: thyroid hormone; rat; behavioral analysis; attention deficit; impulsiveness; ADHD; environmental endocrine disrupter; 内分泌攪乱化学物質

Mother rats were treated with MMI (anti-thyroid drug) by adding it to the drinking water at the concentrations of 0, 0.002, or 0.02% from the gestational day 15 to the postnatal day 21. Twelve weeks after the birth, all rats received a target detection task or a differential reinforcement of low rate (DRL) 20 s task in an operant chamber.1, Target detection task : The target (light) was presented after an ITI. If the rats responded to the target within a time limit, a food pellet was delivered as a reward (hit response). The ITIs were 10, 17.4, 30, and 52.5 s and the time limits were 16, 8, and 4 s. As the results, male and female rats treated with 0.02% MMI reduced % hit response. The hit response was decreased as the ITI and the time limit became shorter. Rats need to prepare to the new target and respond to it quickly under the conditions of shorter ITIs and shorter time limits. We propose that hypothyroid rats do not sustain attention to a target.2, DRL 20 s task : In this test, rats need to respond to the lever after more than or equal to 20 s since the previous response to receive a food reward. The male rats treated with 0.02% MMI displayed a tendency not to be able to wait for 20 s and control their behavior. Taken together, these data give support to the idea that thyroid hormone inhibition causes impulsiveness.

从妊娠第15天到出生后第21天，在饮水中分别加入0.002、0.02%和0.02%的抗甲状腺药物(MMI)。出生后12周，所有大鼠在手术室接受靶点检测任务或低速率差向强化20 S任务。1、靶点检测任务：靶点(光)在ITI后呈现。如果大鼠在一定时间内对目标做出反应，就会得到一个食物颗粒作为奖励(点击反应)。致伤时间分别为10、17.4、30、52.5 S，致伤时间分别为16、8、4只S。结果表明，0.02%MMI组雌雄大鼠的击打反应百分率降低。随着ITI和时限的缩短，HIT反应降低。大鼠需要为新的靶点做好准备，并在较短的ITI和较短的时间限制的条件下对其做出快速反应。我们建议甲状腺功能减退大鼠不持续注意一个靶点2、DRL20 S任务：在本次测试中，大鼠需要在反应杠杆大于或等于20 S之前反应后才能获得食物奖励。0.02%MMI处理的雄性大鼠表现出不能等到20岁的S和控制它们的行为的倾向。总而言之，这些数据支持了甲状腺激素抑制会导致冲动的观点。

项目成果

Hypothyroid rats exhibit attention deficits in a target detection task

甲状腺功能减退大鼠在目标检测任务中表现出注意力缺陷

• 发表时间: 2006
• 期刊: Organohalogen Compounds 68
• 作者: WADA;H.
• 通讯作者: H.

Neurobehavioral effects of hypothyroidism on the next generation in the rat III. -Hit response in a target detection task-.

甲状腺功能减退症对大鼠下一代的神经行为影响 III。

• 发表时间: 2006
• 期刊: The Japanese Journal of Animal Psychology 2
• 作者: WADA;H.
• 通讯作者: H.

Behavioral Psychology-the way of the contributions to our society.

行为心理学——为社会做出贡献的方式。

• 发表时间: 2006
• 作者: IWAMOTO;T.;WADA;H.
• 通讯作者: H.

Neurobehavioral effects of hypothyroidism on the next generation in the rat IV. A target detection task and response time-.

甲状腺功能减退症对大鼠 IV 下一代的神经行为影响。

• 发表时间: 2006
• 期刊: The 70^<th> Annual meeting of Japanese Psychological Association Abstract book
• 作者: WADA;H.
• 通讯作者: H.

Effects of hypothyroidism on target detection performance in the rat.

甲状腺功能减退症对大鼠目标检测性能的影响。

• 发表时间: 2006
• 期刊: The 9^<th> Annual meeting of Japan Society of Endocrine Disrupters Research, Abstract book
• 作者: WADA;H.
• 通讯作者: H.