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Development of new titanium alloys with superior biocompatibility

开发具有优异生物相容性的新型钛合金

基本信息

批准号：
05558107
负责人：
HAMANAKA Hitoshi
金额：
$ 5.7万
依托单位：
Tokyo Medical and Dental University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Developmental Scientific Research (B)
财政年份：
1993
资助国家：
日本
起止时间：
1993 至 1995
项目状态：
已结题

项目摘要

To develop new biocompatible titanium alloys in this research project, the binary alloy of titanium and zirconium, which is also known as a biocompatible metallic element, was investigated. The tensile strength of the binary alloy was 900-950 MPa when the contents of titanium and zirconium were higher than 30% each, while those of the two elements were 300-350 MPa. In addition, the strength increased with a third element, which suggests the possibility of a metallic biomaterial possessing even higher strength.In an immersion test, the amount of released ions from titanium-zirconium alloy was considerably lower than those from the pure component metals. Biocompatibility of the alloy was examined by a subcutaneous implantation test using rats. As a result, titanium-zirconium alloy was proved to be more biocompatible than titanium.Dental casting of Ti-6Al-7Nb alloy was also investigated with the aim of improving the biocompatibility and the castability of Ti-6Al-4V alloy. Although the tensile strength of Ti-6Al-7Nb casting was slightly lower than that of Ti-6Al-4V,the elongation of the former was about 7%, much larger than that of the latter. The mechanical property of Ti-6Al-7Nb was less scattered and was evaluated to be more reliable by better castability. Therefore, Ti-6Al-7Nb was proved to be practicable enough as a dental casting alloy.In addition, mechanical properties of TiAl-base alloys were examined. TiAl-base alloy is an intermetallic compound and a promising heat-resistant material. The strength of this alloy increased by the addition of niobium, and it is thought to be another candidate for a metallic biomaterial.

为了开发新的生物相容性钛合金，在本研究项目中，钛和锆的二元合金，这也被称为生物相容性金属元素，进行了研究。当钛、锆含量均大于30%时，合金的抗拉强度为900-950 MPa，而钛、锆含量均大于30%时，合金的抗拉强度为300-350 MPa。此外，强度增加的第三个元素，这表明可能的金属生物材料具有更高的strength.In浸泡测试中，从钛锆合金释放的离子的量是相当低的那些从纯组分金属。通过大鼠皮下植入试验研究了合金的生物相容性。本文还对Ti-6Al-7 Nb合金进行了牙科铸造研究，旨在提高Ti-6Al-4V合金的生物相容性和铸造性能。Ti-6Al-7 Nb合金铸件的抗拉强度略低于Ti-6Al-4V合金，但延伸率约为7%，远大于Ti-6Al-4V合金。Ti-6Al-7 Nb合金的力学性能分散较小，具有更好的可铸性，因此被评价为更可靠。因此，Ti-6Al-7 Nb作为牙科铸造合金是可行的。TiAl基合金是一种金属间化合物，是一种很有前途的耐热材料。这种合金的强度通过添加铌而增加，并且它被认为是金属生物材料的另一个候选者。