Effects of Poly(ethylene glycol) Immunogenicity on Implant Biocompatibility

聚乙二醇免疫原性对植入物生物相容性的影响

基本信息

  • 批准号:
    10798522
  • 负责人:
  • 金额:
    $ 2.97万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-09-15 至 2026-06-30
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY Poly(ethylene glycol) (PEG) based hydrogels are widely used in medical devices and are being studied for the delivery of protein and cellular therapeutics. While these biomaterials are widely regarded as biologically inert, concerns over PEG’s immunogenicity have emerged in recent years. It has been estimated that 20-30% of the population has antibodies against PEG due to exposure via pharmaceuticals, cosmetics, and other PEG- containing products. While an anti-PEG immune response has been found to reduce the efficacy of intravenously administered PEGylated drugs, the impact on the biocompatibility of PEG hydrogels has not previously been studied and is currently unknown. To address this knowledge gap, this project has two Specific Aims that encompass comprehensive in vivo testing to evaluate the host response to PEG hydrogels of varying physical and chemical properties. In these experiments, PEG hydrogels will be implanted subcutaneously in mice, and the host response will be evaluated at early, intermediate, and late timepoints using histology, immunohistochemistry, flow cytometry, and blood testing. The key comparison in these experiments will be between animals conditioned to mount an anti-PEG response and immunologically naïve controls. The project has two Specific Aims. Aim 1 focuses on PEG hydrogel formulations that lack hydrolytically and enzymatically cleavable linkers. Hydrogels that differ in modulus, crosslinking chemistry, and functionalization with cell-adhesive peptides will be systematically studied. Aim 2 focuses on PEG hydrogel formulations that contain hydrolytically and enzymatically degradable linkers. In addition to evaluating the host response, the impact of the anti-PEG immune response on the in vivo degradation rate of these hydrogels will be investigated via non-invasive imaging in a longitudinal study. The results of this project will either alleviate concerns over PEG immunogenicity for biomaterial implants or motivate future investigations on strategies to mitigate its effects.
项目总结

项目成果

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Daniel Alge其他文献

Daniel Alge的其他文献

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{{ truncateString('Daniel Alge', 18)}}的其他基金

ALTERING THE IMMUNE LANDSCAPE TO AUGMENT BONE REGENERATION
改变免疫景观以增强骨再生
  • 批准号:
    10727797
  • 财政年份:
    2023
  • 资助金额:
    $ 2.97万
  • 项目类别:
Development of a minimally invasive optical biosensor to improve hyperphosphatemia management
开发微创光学生物传感器以改善高磷血症管理
  • 批准号:
    10742278
  • 财政年份:
    2023
  • 资助金额:
    $ 2.97万
  • 项目类别:
Effects of Poly(ethylene glycol) Immunogenicity on Implant Biocompatibility
聚乙二醇免疫原性对植入物生物相容性的影响
  • 批准号:
    10504301
  • 财政年份:
    2022
  • 资助金额:
    $ 2.97万
  • 项目类别:
Effects of Poly(ethylene glycol) Immunogenicity on Implant Biocompatibility
聚乙二醇免疫原性对植入物生物相容性的影响
  • 批准号:
    10697334
  • 财政年份:
    2022
  • 资助金额:
    $ 2.97万
  • 项目类别:
Effects of Poly(ethylene glycol) Immunogenicity on Implant Biocompatibility
聚乙二醇免疫原性对植入物生物相容性的影响
  • 批准号:
    10809875
  • 财政年份:
    2022
  • 资助金额:
    $ 2.97万
  • 项目类别:
Impact of the Anti-PEG Response on the Efficacy of PEG Hydrogel-Mediated Bone Regeneration
抗 PEG 反应对 PEG 水凝胶介导的骨再生功效的影响
  • 批准号:
    9890921
  • 财政年份:
    2019
  • 资助金额:
    $ 2.97万
  • 项目类别:
Osteoinductive Microgel-Based Scaffolds for hMSC Delivery
用于 hMSC 输送的骨诱导微凝胶支架
  • 批准号:
    9299161
  • 财政年份:
    2017
  • 资助金额:
    $ 2.97万
  • 项目类别:

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