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Intrahepaticparasite infection and cholangiocarcinomas

肝内寄生虫感染和胆管癌

基本信息

批准号：
05042006
负责人：
ITO Nobuyuki
金额：
$ 2.05万
依托单位：
Nagoya City University
依托单位国家：
日本
项目类别：
Grant-in-Aid for international Scientific Research
财政年份：
1993
资助国家：
日本
起止时间：
1993 至无数据
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-05042006/
关键词：
Clonorchis siensis Korea cholangiocellular carcinoma hepatocellular carcinoma

项目摘要

The northeast area of Thailand where the liver fluke parasite Opisthorchis viverrini (OV) is endemic and economically disadvantaged people eat raw fish harboring parasite metacercariae has a high incidence of cholangiocellular cancer. Previously we have demonstrated that OV infestation significantly enhances development of cholangiocellular carcinoma in hamster livers and that prolonged inflammation and regenerative epithelial hyperplasia may play important roles in development of cholangiocellular carcinomas in OV infested livers. The present investigation was performed to see whether there is any association between development of cholangiocellular carcinomas and infection with Clonorchis sinensis in Korea.With assistance from Professor Soo Song, Department of Parasitology, College of Medicine Pusan National university, we collected pathological data on over 440 liver tumors surgically removed at Pusan National University and Kosin Medical College and Gospel Hospital in Pusan, Korea. Of these, 432 cases aged more than 20 years old were subjected to analysis. They comprised 337 males (mean age 50.9 years old (27-73 yrs)) and 95 females (mean age 51.2 years old (21-76 yrs)). Forty nine males (14.5%) and 12 females (12.6%) were revealed to be infected with liver flukes by stool examination and/or histopathology of the livers and 88 males and 24 females were negative for both examinations. Hepatocellular carcinomas and cholangiocellular carcinomas were present in 97 cases and 14 cases, respectively among the 112 infection-negative cases, whereas they were found in 32 and 28, respectively, of the 61 infection-positive cases. A significant difference (P<0.001, Fischer exact analysis) in the incidences of each type of carcinoma was evident between the infection-positive and negative groups.Thus, these results clearly demonstrate that infection with Clonorchis sinensis is also a risk factor for development of cholangiocellular carcinomas.

在泰国东北部地区，肝吸虫寄生虫Viverrini后睾吸虫（OV）是地方病，经济上处于不利地位的人吃生鱼窝藏寄生虫囊蚴，胆管细胞癌的发病率很高。以前，我们已经证明，OV感染显着增强仓鼠肝脏胆管细胞癌的发展，长期的炎症和再生上皮增生可能在OV感染的肝脏胆管细胞癌的发展中发挥重要作用。目前的调查，以了解是否有任何关联的发展之间的胆管细胞癌和感染华支睾吸虫在Korea.With教授的协助下，寄生虫学系，医学大学釜山国立大学，我们收集了超过440例肝肿瘤手术切除的病理数据，在釜山国立大学和Kosin医学院和福音医院，韩国。其中，432例年龄大于20岁的病例进行了分析。他们包括337名男性（平均年龄50.9岁（27-73岁））和95名女性（平均年龄51.2岁（21-76岁））。经粪便检查和/或肝脏组织病理学检查发现49名男性（14.5%）和12名女性（12.6%）感染肝吸虫，88名男性和24名女性两项检查均为阴性。在112例感染阴性病例中，肝细胞癌和胆管细胞癌分别为97例和14例，而在61例感染阳性病例中，肝细胞癌和胆管细胞癌分别为32例和28例。感染阳性组与阴性组之间各型癌的发生率有显著性差异（P<0.001），表明华支睾吸虫感染也是胆管细胞癌发生的危险因素。