Pathological investigation on human bladder epithelium

本文从313例男性和女性的尸体解剖中获得了肉眼可见的正常膀胱，并在显微镜下进行了检查。增生性病变如布伦氏窝和腺性膀胱炎在所有年龄和性别的病例中都很常见。化生病变如柱状或立方状化生和鳞状化生较少见。这两种类型的病变与年龄无关，但鳞状皮化生在女性中比男性更常见。四种病变的好发部位分别为三角肌和前壁。16.3%的男性和10.6%的女性病例出现增生，6.8%的男性和5.7%的女性病例出现发育不良。这两种类型的病变在老年人中比年轻人更常见。两种类型的病变均与慢性炎症无关。一例原位癌发现于男性。这些数据和膀胱的定位表明，这些良性增生和化生病变都不是发育不良或原位癌的发展。一些酶参与药物代谢，膜功能和细胞生理学的其他领域的表达被研究的人膀胱，重点是肿瘤病变。过渡细胞癌的特征是碱性磷酸酶（ALP）降低，谷氨酰转肽酶（GGT）升高，< β >-葡萄糖醛酸酶（< β >- gl），琥珀酸脱氢酶（SD）和葡萄糖-6-磷酸脱氢酶（G6PD）升高。此外，针对不同细胞色素P450种类和微粒体环氧化物水解酶（mEHb）特异性抗体的结合在肿瘤中显示出共同的升高。

Urinary bladder that appeared normal macroscopically were obtained from 313 autoposy cases of both sexes and examined microscopically. Proliferative lesions such as Brunn's nests and cystitis glandularis were frequent in cases of all ages and both sexes. Metaplastic lesions such as columnar or cuboidal metaplasia and squamous metaplasia were less frequent. These two types of lesions were not related to age, but squamous metaplasia was more common in females than in males. The sites of predilection for there 4 types of lesions were the trihone and anterior wall. Hyperplasia was observed in 16.3% of the male and 10.6% of the female cases, and dysplasia in 6.8% of the male and 5.7% of the female cases. Both types of lesions were more frequent in older than younger cases. Neither type of lesions was related to chronic inflammation. One case of carcinoma in situ was found in a male. These data and mapping of the bladders indicated that none of these benign proliferative and metaplastic lesions were the development of dysplasia or carcinoma in situ.Expression of a number of enzymes involved in drug metabolism, membrane function and other areas of cellular physiology was investigated on the urinary bladder of man with emphasis on neoplastic lesions. Thransitional cell carctnoma were characterized by decreased alkaline phosphatase (ALP) and increased gamma glutamyl transpeptidase (GGT), <beta>- glucuronidase (<beta>-Gl), succinate dehydrogenase (SD) and glucose-6-phosphate dehydrogenase (G6PD). In addition, binding for antibodies specific for different cytochrome P450 species and microsomal epoxide hydrolase (mEHb) demonstrated a common elevation in tumors.