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Pathological investigation on human bladder epithelium

人膀胱上皮的病理学研究

基本信息

批准号：
60480147
负责人：
ITO Nobuyuki
金额：
$ 2.37万
依托单位：
Nagoya City University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1985
资助国家：
日本
起止时间：
1985 至 1987
项目状态：
已结题

项目摘要

Urinary bladder that appeared normal macroscopically were obtained from 313 autoposy cases of both sexes and examined microscopically. Proliferative lesions such as Brunn's nests and cystitis glandularis were frequent in cases of all ages and both sexes. Metaplastic lesions such as columnar or cuboidal metaplasia and squamous metaplasia were less frequent. These two types of lesions were not related to age, but squamous metaplasia was more common in females than in males. The sites of predilection for there 4 types of lesions were the trihone and anterior wall. Hyperplasia was observed in 16.3% of the male and 10.6% of the female cases, and dysplasia in 6.8% of the male and 5.7% of the female cases. Both types of lesions were more frequent in older than younger cases. Neither type of lesions was related to chronic inflammation. One case of carcinoma in situ was found in a male. These data and mapping of the bladders indicated that none of these benign proliferative and metaplastic lesions were the development of dysplasia or carcinoma in situ.Expression of a number of enzymes involved in drug metabolism, membrane function and other areas of cellular physiology was investigated on the urinary bladder of man with emphasis on neoplastic lesions. Thransitional cell carctnoma were characterized by decreased alkaline phosphatase (ALP) and increased gamma glutamyl transpeptidase (GGT), <beta>- glucuronidase (<beta>-Gl), succinate dehydrogenase (SD) and glucose-6-phosphate dehydrogenase (G6PD). In addition, binding for antibodies specific for different cytochrome P450 species and microsomal epoxide hydrolase (mEHb) demonstrated a common elevation in tumors.

从313例男性和女性的尸体解剖病例中获得肉眼观察正常的膀胱，并进行显微镜检查。在所有年龄和性别的病例中，诸如布伦氏巢和腺性膀胱炎的炎性病变是常见的。化生性病变，如柱状或立方化生和鳞状化生较少见。这两种类型的病变与年龄无关，但鳞状上皮化生在女性比男性更常见。这4种病变好发部位均为前壁和前壁。男性16.3%，女性10.6%;男性6.8%，女性5.7%。这两种类型的病变更常见于老年人比年轻的情况下。两种类型的病变均与慢性炎症无关。原位癌1例，男性。这些数据和映射的膀胱表明，没有这些良性增生和化生病变的发育异常或原位癌。表达的一些酶参与药物代谢，膜功能和其他领域的细胞生理学研究的人膀胱肿瘤病变的重点。转化细胞癌的特征是碱性磷酸酶（ALP）降低，γ-谷氨酰转肽酶（GGT）、β<beta>-葡萄糖醛酸酶（<beta>-Gl）、琥珀酸脱氢酶（SD）和葡萄糖-6-磷酸脱氢酶（G6 PD）升高。此外，不同细胞色素P450种类和微粒体环氧化物水解酶（mEHb）特异性抗体的结合在肿瘤中表现出常见的升高。