Seroepidemiological study of stomach cancer in China

在中国沈阳市进行了一项血清流行病学研究，以研究几种血清标志物（胃蛋白酶原I和II、抗幽门螺杆菌抗体IgG和β -胡萝卜素）与胃癌的相关性。血清标志物在人群中的分布随机抽取沈阳市献血者的血清。按年龄组别（20-29岁、30-39岁、40-49岁、50-59岁）和性别收集50份样本，最终收集样本380份。对这280个样本进行了分析。1)胃蛋白酶原I和II：沈阳地区血清胃蛋白酶原I水平男性高于宫城县，女性低于宫城县。沈阳市胃蛋白酶原测定慢性萎缩性胃炎的患病率低于宫城市。2)幽门螺杆菌抗体：沈阳市的幽门螺杆菌感染率低于宫城市，尤其是男性。3)慢性萎缩性胃炎与幽门螺杆菌感染：估计幽门螺杆菌抗体阳性者患慢性萎缩性胃炎的比值比为9.9.4)β -胡萝卜素：沈阳市与宫城市之间β -胡萝卜素水平无差异。病例-对照研究病例以沈阳市某医院新诊断的胃癌患者为研究对象，对照以非肿瘤患者为研究对象。到目前为止，已收集了50例病例和150例对照。初步结果显示，胃癌家族史、饮食不规律、爱吃咸食、吸烟等会增加患胃癌的风险，而肉类、鸡蛋、绿色蔬菜、水果等则会降低患胃癌的风险。尚未进行包括血清标记物在内的分析，因为所有样本将在样本达到目标值（200例病例和600例对照）后同时进行分析。

A seroepidemiological study in Shenyang city, China, was performed to examine the correlation between several serum markers (pepsinogen I and II, IgG anti-Helicobacter pylori antibody and beta-carotene) and stomach cancer.1. Distribution of serum markers in the populationSerum samples were collected randomly from the blood donors living in Shenyang city. Fifty samples by age-group (20-29, 30-39, 40-49, 50-59) and sex were to be collected, and finally 380 samples were collected. Of these 280 samples were assayed.1) Pepsinogen I and II : Serum level of pepsinogen I of the samples from Shenyang was higher in males and lower in females than those from Miyagi Prefecture. The prevalence of chronic atrophic gastritis determined by pepsinogen was lower in Shenyang than in Miyagi.2) H.pylori antibody : The prevalence of H.pylori infection is lower in Shenyang than in Miyagi, especially among males.3) Chronic atrophic gastritis and H.pylori infection : Odds ratio of chronic atrophic gastritis for the subjects having H.pylori antibody was estimated at 9.9.4) Beta-carotene : No difference in the level of beta-carotene was observed between Shenyang and Miyagi.2. Case-control studyCase subjects were the patients with stomach cancer newly diagnosed in the hospital in Shenyang, and control subjects were the patients with the diseases other than cancer. Fifty cases and 150 controls have been collected until now.Preliminary results show that family history of stomach cancer, having diet irregularly, favoring salt foods, present smoking etc. increased the risk of stomach cancer and meat, eggs, green vegetables, fruits etc. decreased the risk. Analyses including the serum markers have not yet performed since all samples will be assayed at the same time after the samples reach to objective number (200 case and 600 controls).