Seroepidemiological study of stomach cancer in China

我国胃癌血清流行病学研究

• 批准号: 05042001
• 负责人: FUKAO Akira
• 金额: $ 2.05万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for international Scientific Research
• 财政年份: 1993
• 资助国家: 日本
• 起止时间: 1993 至 无数据
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-05042001/
• 关键词: stomach cancer; pepsinogen; Helicobacter pylori; beta-carotene; chronic atrophic gastritis; seroepidemiology

A seroepidemiological study in Shenyang city, China, was performed to examine the correlation between several serum markers (pepsinogen I and II, IgG anti-Helicobacter pylori antibody and beta-carotene) and stomach cancer.1. Distribution of serum markers in the populationSerum samples were collected randomly from the blood donors living in Shenyang city. Fifty samples by age-group (20-29, 30-39, 40-49, 50-59) and sex were to be collected, and finally 380 samples were collected. Of these 280 samples were assayed.1) Pepsinogen I and II : Serum level of pepsinogen I of the samples from Shenyang was higher in males and lower in females than those from Miyagi Prefecture. The prevalence of chronic atrophic gastritis determined by pepsinogen was lower in Shenyang than in Miyagi.2) H.pylori antibody : The prevalence of H.pylori infection is lower in Shenyang than in Miyagi, especially among males.3) Chronic atrophic gastritis and H.pylori infection : Odds ratio of chronic atrophic gastritis for the subjects having H.pylori antibody was estimated at 9.9.4) Beta-carotene : No difference in the level of beta-carotene was observed between Shenyang and Miyagi.2. Case-control studyCase subjects were the patients with stomach cancer newly diagnosed in the hospital in Shenyang, and control subjects were the patients with the diseases other than cancer. Fifty cases and 150 controls have been collected until now.Preliminary results show that family history of stomach cancer, having diet irregularly, favoring salt foods, present smoking etc. increased the risk of stomach cancer and meat, eggs, green vegetables, fruits etc. decreased the risk. Analyses including the serum markers have not yet performed since all samples will be assayed at the same time after the samples reach to objective number (200 case and 600 controls).

在沈阳市进行了一项血清流行病学研究，以检查几种血清标志物（胃蛋白酶原I和II、抗幽门螺杆菌抗体IgG和β-胡萝卜素）与胃癌的相关性.血清标志物在人群中的分布随机抽取沈阳市无偿献血者的血清样本。按年龄组（20-29岁、30-39岁、40-49岁、50-59岁）和性别采集50份样本，最终采集380份样本。1）胃蛋白酶原Ⅰ和Ⅱ：沈阳地区男性胃蛋白酶原Ⅰ水平高于宫城地区，女性胃蛋白酶原Ⅰ水平低于宫城地区。胃蛋白酶原测定的沈阳市慢性萎缩性胃炎患病率低于宫城市。2）幽门螺杆菌抗体：沈阳市幽门螺杆菌感染患病率低于宫城，尤其是男性。3）慢性萎缩性胃炎和幽门螺杆菌感染：幽门螺杆菌抗体阳性受试者慢性萎缩性胃炎的比值比估计为9.9。4）β-胡萝卜素：沈阳市和宫城县的β-胡萝卜素水平没有差异.病例对照研究病例组为沈阳市某医院新诊断的胃癌患者，对照组为非肿瘤性疾病患者。初步结果表明，胃癌家族史、饮食不规律、喜食盐、吸烟等因素增加胃癌发病的危险性，而肉类、蛋类、绿色蔬菜、水果等降低胃癌发病的危险性。尚未进行包括血清标志物在内的分析，因为所有样本将在样本达到目标数量（200例病例和600例对照）后同时进行分析。