Seroepidemiological study of stomach cancer in China

对沈阳市中国进行了一项血清流行病学研究，以探讨几种血清标志物(胃蛋白酶原I和II、抗幽门螺杆菌抗体Ig G和β-胡萝卜素)与胃癌的相关性。血清标志物在人群中的分布随机抽取沈阳市献血员血清标本。按年龄(20~29岁、30~39岁、40~49岁、50~59岁)和性别收集样本50份，共收集样本380份。1)胃蛋白酶原I、II：沈阳地区血清胃蛋白酶原I水平男性高于宫城县，女性低于宫城县。2)幽门螺杆菌抗体：沈阳地区幽门螺杆菌感染率低于宫城地区，尤其是男性。3)慢性萎缩性胃炎与幽门螺杆菌感染：幽门螺杆菌抗体阳性者患慢性萎缩性胃炎的优势比估计为9.9。4)β-胡萝卜素：沈阳地区与宫城地区的β-胡萝卜素水平无差异。病例对照研究病例组为沈阳市医院新诊断的胃癌患者，对照组为非癌症患者。现已收集病例50例，对照150例。初步结果显示，胃癌家族史、饮食不规律、偏食盐类食品、现吸烟等可增加患胃癌的风险，而肉类、鸡蛋、绿色蔬菜、水果等可降低患胃癌的风险。包括血清标志物在内的分析尚未进行，因为所有样本将在样本达到目标数量(200例病例和600名对照)后同时进行检测。

A seroepidemiological study in Shenyang city, China, was performed to examine the correlation between several serum markers (pepsinogen I and II, IgG anti-Helicobacter pylori antibody and beta-carotene) and stomach cancer.1. Distribution of serum markers in the populationSerum samples were collected randomly from the blood donors living in Shenyang city. Fifty samples by age-group (20-29, 30-39, 40-49, 50-59) and sex were to be collected, and finally 380 samples were collected. Of these 280 samples were assayed.1) Pepsinogen I and II : Serum level of pepsinogen I of the samples from Shenyang was higher in males and lower in females than those from Miyagi Prefecture. The prevalence of chronic atrophic gastritis determined by pepsinogen was lower in Shenyang than in Miyagi.2) H.pylori antibody : The prevalence of H.pylori infection is lower in Shenyang than in Miyagi, especially among males.3) Chronic atrophic gastritis and H.pylori infection : Odds ratio of chronic atrophic gastritis for the subjects having H.pylori antibody was estimated at 9.9.4) Beta-carotene : No difference in the level of beta-carotene was observed between Shenyang and Miyagi.2. Case-control studyCase subjects were the patients with stomach cancer newly diagnosed in the hospital in Shenyang, and control subjects were the patients with the diseases other than cancer. Fifty cases and 150 controls have been collected until now.Preliminary results show that family history of stomach cancer, having diet irregularly, favoring salt foods, present smoking etc. increased the risk of stomach cancer and meat, eggs, green vegetables, fruits etc. decreased the risk. Analyses including the serum markers have not yet performed since all samples will be assayed at the same time after the samples reach to objective number (200 case and 600 controls).