Delineating the underlying reasons for the racial disparity in gastric cancer incidence in the United States
描绘美国胃癌发病率种族差异的根本原因
基本信息
- 批准号:10518553
- 负责人:
- 金额:$ 72.48万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-09-01 至 2027-08-31
- 项目状态:未结题
- 来源:
- 关键词:AffectAntibioticsAntibodiesAntibody ResponseAsian populationAtrophicAtrophic GastritisBacteriaBiologicalBiological AssayBiological MarkersBismuthBlack PopulationsBody mass indexCancer EtiologyCellsCharacteristicsChronic stressClinical TrialsCohort StudiesCommunitiesCountryCrowdingDataDevelopmentDiagnosisDiagnosticDietDiseaseFar EastFundingFutureGenesGoalsHelicobacter InfectionsHelicobacter pyloriHelicobacter pylori induced gastric cancerHepatitis BHepatitis C virusHispanic PopulationsHouseholdHuman papilloma virus 31Immune responseIncidenceIndividualInfectionInfectious AgentInflammationKnowledgeLaboratory StudyLesionMalignant NeoplasmsMass ScreeningMediatingMinority GroupsModelingNeighborhoodsNested Case-Control StudyNot Hispanic or LatinoPatientsPatternPepsinogen APepsinogensPersonsPopulation HeterogeneityPrevalencePrevention GuidelinesProspective cohortProstate, Lung, Colorectal, and Ovarian Cancer Screening TrialProteinsProton Pump InhibitorsRaceRiskRisk FactorsRoleScreening for Gastric CancerSmokingSmoking StatusSocietiesSpecimenStomachSurvival RateTimeUnited StatesVirulence FactorsWomen&aposs Healthblack mencancer diagnosiscancer riskcarcinogenicitycohortcost effectiveethnic minorityfallsgastric cancer preventionhigh riskimprovedindividualized preventionmalignant stomach neoplasmmenmortalitymortality disparitymulti-ethnicnovelpeople of colorpremalignantracial and ethnicracial differenceracial disparityresidential segregationrisk predictionscreening guidelinessocial health determinantstool
项目摘要
ABSTRACT
The burden of gastric cancer falls disproportionately on racial/ethnic minorities in the US, with incidence rates among
Blacks, Asians, and Hispanics two- to three-fold higher than that among non-Hispanic whites. Further, individuals who self-
identify as belonging to any of these three groups are also more likely to die from gastric cancer, and comparing Black
men to White men, specifically, this mortality disparity is greater than that for all other cancers. In the US, gastric cancer
has a particularly low survival rate (32% at 5-years) as it is generally asymptomatic until late-stage, when treatment is no
longer effective. Each year in the US, 26,000 people are diagnosed with gastric cancer, and over 10,000 people die of the
disease. Moreover, the racial disparity in gastric cancer continues to grow over time. And yet, the underlying reasons for
this racial disparity in gastric cancer incidence in the US are substantially understudied. The predominant cause of gastric
cancer is infection with the common bacterium, Helicobacter pylori (H. pylori). H. pylori is more prevalent among people
of color than non-Hispanic whites, and, in fact, H. pylori is the world’s single leading carcinogenic infectious agent,
responsible for an estimated 36.9% of the over 2.2 million infection-associated cancers diagnosed in 2018, more even
than those attributed to human papillomavirus (31.5%), or the Hepatitis B and C viruses combined (23.5%). Currently,
however, little is known about whether the disparity in gastric cancer is a result of differences in H. pylori prevalence, host
response to H. pylori, or differences in other risk factors that might affect the development of gastric cancer. These
potential other risk factors include key individual and neighborhood characteristics that differ greatly by race, such as
household crowding and residential segregation, which could increase the risk of H. pylori infection, contribute to chronic
stress, and induce a more severe immune response. Our goal is to fill the gap in knowledge of risk factors for H. pylori-
associated gastric cancer to provide the understanding of the underlying factors that indicate who is at high risk of gastric
cancer in the US. To do this, we will build a nested case-control study of approximately 800 non-cardia gastric cancer cases
and 2:1 matched controls, utilizing prospective cohort data from a diverse population in the US (67% non-white) from 4
NCI-funded cohorts with pre-diagnostic specimens available: Multiethnic Cohort Study (MEC); Prostate, Lung, Colorectal,
and Ovarian Cancer Screening Trial (PLCO); Southern Community Cohort Study (SCCS); and Women’s Health Initiative
(WHI). We will assay these biospecimens for antibody levels to H. pylori-specific proteins and for pepsinogen (a validated
marker of gastric atrophy), thoroughly assess individual and neighborhood factors that are associated with gastric cancer
risk, and determine what drives the differences in race by H. pylori antibody levels and atrophy and resulting gastric cancer
risk. Finally, we will develop an integrated “cells to society” modeling framework to assess the impact of social
determinants of health on the patterns of H. pylori antibody levels, gastric atrophy and resulting disparities in gastric
cancer. Ultimately, these findings will provide the information needed to allow for targeting of high-risk patients for the
clinical trials necessary to create screening guidelines for the prevention and early detection of gastric cancer in the US,
and will help clinicians with precision prevention by laying the groundwork for the building of a risk prediction tool.
摘要
项目成果
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{{ truncateString('MEIRA EPPLEIN', 18)}}的其他基金
Delineating the underlying reasons for the racial disparity in gastric cancer incidence in the United States
描绘美国胃癌发病率种族差异的根本原因
- 批准号:
10685530 - 财政年份:2022
- 资助金额:
$ 72.48万 - 项目类别:
Project 2: Racial differences in host immune response and gastric carcinogenesis: Translating underlying biology to promote gastric cancer interception
项目2:宿主免疫反应和胃癌发生的种族差异:转化基础生物学以促进胃癌拦截
- 批准号:
10037509 - 财政年份:2020
- 资助金额:
$ 72.48万 - 项目类别:
Project 2: Racial differences in host immune response and gastric carcinogenesis: Translating underlying biology to promote gastric cancer interception
项目2:宿主免疫反应和胃癌发生的种族差异:转化基础生物学以促进胃癌拦截
- 批准号:
10263344 - 财政年份:2020
- 资助金额:
$ 72.48万 - 项目类别:
Helicobacter pylori protein-specific antibodies and colorectal cancer risk
幽门螺杆菌蛋白特异性抗体与结直肠癌风险
- 批准号:
8894172 - 财政年份:2015
- 资助金额:
$ 72.48万 - 项目类别:
Helicobacter pylori blood biomarker for gastric cancer risk in East Asia
东亚胃癌风险的幽门螺杆菌血液生物标志物
- 批准号:
8593567 - 财政年份:2013
- 资助金额:
$ 72.48万 - 项目类别:
Helicobacter pylori blood biomarker for gastric cancer risk in East Asia
东亚胃癌风险的幽门螺杆菌血液生物标志物
- 批准号:
8699730 - 财政年份:2013
- 资助金额:
$ 72.48万 - 项目类别:
Helicobacter pylori blood biomarker for gastric cancer risk in East Asia
东亚胃癌风险的幽门螺杆菌血液生物标志物
- 批准号:
9091479 - 财政年份:2013
- 资助金额:
$ 72.48万 - 项目类别:
Helicobacter pylori blood biomarker for gastric cancer risk in East Asia
东亚胃癌风险的幽门螺杆菌血液生物标志物
- 批准号:
9464051 - 财政年份:2013
- 资助金额:
$ 72.48万 - 项目类别:
Helicobacter pylori subtypes, inflammation, and gastric cancer risk
幽门螺杆菌亚型、炎症和胃癌风险
- 批准号:
8677779 - 财政年份:2011
- 资助金额:
$ 72.48万 - 项目类别:
Helicobacter pylori subtypes, inflammation, and gastric cancer risk
幽门螺杆菌亚型、炎症和胃癌风险
- 批准号:
8481198 - 财政年份:2011
- 资助金额:
$ 72.48万 - 项目类别:
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