Seroepidemiological study on stomach cancer in China

我国胃癌血清流行病学研究

• 批准号: 06042001
• 负责人: FUKAO Akira
• 金额: $ 4.48万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for international Scientific Research
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06042001/
• 关键词: stomach cancer; pepsinogen; Helicobacter pylori; beta-carotene; (chronic)atrophic gastritis; seroepidemiology; 中国; 症例対照研究; ヘリコパクタ・ピロリ; 萎縮性胃炎

A seroepidemiological study in Shenyang City, China, was performed to examine the relation of atrophic gastritis and Helicobacter pylori infection to stomach cancer.1.Prevalence of atrophic gastritis and Helicobacter phlori infection in ChinaSerum samples, collected from blood donors in Shenyang, were analyzed for pepsinogen, lgG Helicobacter pylori antibody and B-carotene, and the results were compared to those from Miyagi, Japan, The prevalence of atrophic gestritis, determined by pepsinogen I AND II,was lower in Shenyang than in Miyagi for both sexes. The prevalence of Helicobacter pylori infection was lower in Snenyang than in Miyagi for males. The serum leves of B-carotene was not different between two areas.2.A case-control study in Shenyang201cases with stomach cancer and 608 hospital controls were interviewed concerning lifestyle and their blood samples were analyzed for pepsinogen and Helicobacter pylori antibody. Family history of gastric cancer, current smoking, frequent intake of salty pickles, atrophic gastritis and Helicobacter phylori infection were incresed the risk of stomach cancer, and frequent intake of salty fish and fresh fruits decresed. These results suggests that atrophic gastritis and Heliorcbacter pyloiinfection play an important role in carcinogenesis of stomach cancer on the individual level

本文对沈阳市萎缩性胃炎和幽门螺杆菌感染与胃癌的关系进行了血清流行病学调查。对沈阳市献血者血清中胃蛋白酶原、lgG幽门螺杆菌抗体和b -胡萝卜素进行分析，并与日本宫城市进行比较。用胃蛋白酶原I和II测定萎缩性子宫炎的患病率，沈阳地区男女均低于宫城市。男性幽门螺杆菌感染率在斯阳低于宫城市。血清b -胡萝卜素水平在两地区间无显著差异。对沈阳市201例胃癌患者和608例医院对照者进行生活方式访谈，并进行胃蛋白酶原和幽门螺杆菌抗体检测。胃癌家族史、吸烟史、经常食用咸菜、萎缩性胃炎和幽门螺杆菌感染增加了胃癌的发生风险，经常食用咸鱼和新鲜水果降低了胃癌的发生风险。这些结果提示萎缩性胃炎和幽门螺旋杆菌感染在个体水平上对胃癌的发生起重要作用