The study of severe maxillofacial disorders

严重颌面部疾病的研究

• 批准号: 05045045
• 负责人: ETO Kazuhiro
• 金额: $ 3.84万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for international Scientific Research
• 财政年份: 1993
• 资助国家: 日本
• 起止时间: 1993 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-05045045/
• 关键词: Maxillofacial Surgery; Maxillofacial Prosthetics; Maxillofacial Orthodontics; Severe Periodontitis (Papillon-Lefevre Syndrome); Maxillofacial Development and Anomalies

Neural crest cells derived from forebrain and midbrain of mouse embryos were cultured separately and performed immunohistochemistry to identify the characteristics of the differentiated cells. Neurons derived from midbrain cultures were more than those from forebrain cultures. Cells which supposed to be chondrocytes were found only in midbrain cultures and melanocyte cells were observed in forebrain cultures. These results mean that the differential potentialities from the both regions seemed to be partly restricted before migrating out from the neuroepithelium.The severe maxillofacial disorders related to the surgery were investigated in two medical facilities and the data during the past 10 years was compared each other. The largest group in malignant tumors was represented by squamous cell carcinoma and more than 40% occurred on the mandible in Thailand and on the tongue in Japan. Of all benign tumors ameloblastoma (51.4%) made the largest group in Thailand and hemangioma (18.8%) in … More Japan. Unilateral cleft lip and palate was the most frequent malformation in both countries. In the data of the maxillofacial fractures men were almost 3 times as many as women. The fractures were caused mainly by traffic accident (72.5%) in Thailand and by fall down (30.0%) in Japan. Concerning TMJ dysfunction ankylosis (87.5%) and condylar hyperplasia (12.5%) were treated surgically in Thailand.Depending on the pathologic conditions several surgical procedures applied in Japan.A clinico-statistical study was performed on patients with severe maxillofacial disorders in Thailand and Japan. Data on the patients and maxillofacial prosthetic cares for them were compared between the two, conspicuous difference was found in many respects that mainly based on the economic status of the nation.A comparative cephalometric study was carried out by using pre- and post surgical orthodontic treatment in both institute. There were 21 cephalometric parameters used in this study. Some similarities in both samples were found, however, a few differences were also recognized. More lingually inclined lower incisor and more increased anterior dental height were found in Thai patient after treatment.Papillon-Lefevre syndrome (PLS) patients were examined and treated. The ELISA titers of the patients against Actinobacillus actinomycetemcomitans (A.a.) decreased after treatment and A.a.could not be detected in bacterial cultures. PLS patients showed positive antibody response to the same antigens of A.a.A.a.seemed to play role to periodontal tissue destruction in PLS patients. Less

分别培养小鼠胚胎前脑和中脑来源的神经脊细胞，免疫组织化学方法鉴定分化细胞的特性。来自中脑培养的神经元多于来自前脑培养的神经元。只有在中脑培养中才能发现本应为软骨细胞的细胞，而在前脑培养中可观察到黑素细胞。这些结果意味着，在从神经上皮细胞迁移出来之前，这两个区域的分化潜力似乎受到了部分限制。与手术相关的严重颌面部疾病在两个医疗机构进行了调查，并对过去10年的数据进行了比较。恶性肿瘤中最大的群体是鳞状细胞癌，在泰国，超过40%的恶性肿瘤发生在下颌骨，在日本，超过40%的恶性肿瘤发生在舌头上。在所有良性肿瘤中，泰国最多的是成釉细胞瘤(51.4%)，…最多的是血管瘤(18.8%更多的日本人。单侧唇腭裂是两国最常见的畸形。在颌面部骨折的数据中，男性几乎是女性的3倍。骨折主要由泰国交通事故(72.5%)和日本跌倒(30.0%)引起。在TMJ功能障碍方面，泰国手术治疗强直(87.5%)和髁突增生症(12.5%)。根据病理情况，日本采用了几种手术方式。对泰国和日本的严重颌面部疾病患者进行了临床统计研究。对两所口腔正畸患者和修复患者的资料进行比较，发现两者在多个方面存在显著差异，主要是基于国家的经济状况。在这项研究中使用了21个头影测量参数。两个样本都发现了一些相似之处，但也发现了一些不同之处。治疗后，泰国患者的下切牙舌侧倾斜度增加，前牙高度增加。对乳头状Lefevre综合征患者进行检查和治疗。用放线菌伴生放线杆菌(A.A.)治疗后下降，细菌培养中未检出A.A.PLS患者对相同抗原的抗体反应阳性，提示其对牙周组织的破坏可能起作用。较少

项目成果

Hasegawa, K., Amagasa, T.: "Oral and Maxillofacial reconstruction using free rectus abdominis myocufaneous flap" J.Cranio-Maxillo-Facial Surg.22. 236-243 (1994)

Hasekawa, K., Amagasa, T.：“使用游离腹直肌肌瓣进行口腔颌面重建”J.Cranio-Maxillo-Facial Surg.22。

Yoshiyuki BABA,Takafumi SUSAMI,Masamitsu UJI,Keiji MORIYAMA,Rong Rong MA,Makoto YAMAMOTO,Nobuyuki MOTOHASHI and Takayuki KURODA: "Topographical relationships between teeth and alveolar arches in patients with unilateral cleft lip and palate after orthodon

Yoshiyuki BABA、Takafumi SUSAMI、Masamitsu UJI、Keiji MORIYAMA、Rong Rong MA、Makoto YAMAMOTO、Nobuyuki MOTOHASHI 和 Takayuki KURODA：“单侧唇腭裂患者正畸后牙齿与牙槽弓的地形关系

加藤嘉之、天願俊永、清水利江子、宇治正光、本端信義、黒田敬之: "顔面非対称症例の正面頭部X線規格顎分析" 日本顎変形症学会雑誌. 4. 87-95 (1994)

Yoshiyuki Kato、Toshinaga Tengan、Rieko Shimizu、Masamitsu Uji、Nobuyoshi Honbata、Noriyuki Kuroda：“面部不对称病例的前头 X 射线标准化颌分析”日本颌畸形协会杂志 4. 87-95 (1994)。

T.Susami,T.Kuroda: "Quantitative evaluation of the shape and the elasticity of repaired cleft lip" Cleft Palate-Craniofacial J.30. 309-312 (1993)

T.Susami，T.Kuroda：“唇裂修复的形状和弹性的定量评估”Cleft Palate-Craniofacial J.30。

天笠光雄: "先天性上唇正中瘻の2例" 日本口蓋裂学会雑誌. 18. 381-385 (1993)

Mitsuo Amagasa：“先天性中线上唇瘘的两例”日本裂腭协会杂志 18. 381-385 (1993)。