Synthetic Studies for Ample Supply of Biologically Active Natural Products
生物活性天然产物充足供应的合成研究
基本信息
- 批准号:05303011
- 负责人:
- 金额:$ 7.17万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Co-operative Research (A)
- 财政年份:1993
- 资助国家:日本
- 起止时间:1993 至 1995
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Reacenty, many biologically active natural products, which are available to the precise investigation of the biological transmission mechanism in molecular level, have been isolated and characterized. However, it is quite dificult to obtain such kind of compounds from natural sources. For example, it is well-known that some spider toxins inhibit the exitement neuro-transmimmision in brain and are suitable tool to investigate such transmission mechanism. Since the gain of these toxins in pure forms from natural sources is impossible, their ample supplies have been required by their syntheses. Irie and his co-workers (Nagasaki University and Hokkaido University) have accomplished a new method to synthesize these toxins using the azide group in the place of amino group for the construction of the polyamine side chains in toxins. This method makes the supply of the considerably large amount of toxins possible. Tkahashi (Tokyo Institute of Technology) has developed a new method which is available to synthesize some biologically active poly-succaride chains. Fujii (Kyoto University) has synthesized some poly-peptides having an possibility to develop of new drug against AIDS.Uemura (Shizuoka Unversity) investigated the toxic substances produced by a marine shell and elucidated the structure of genuin toxin possessing the possibility to design new drug. And all the members of this project have carried out high-lebel of research works evluated all the world and published large number of the reports on international scientific journals.
近年来,许多具有生物活性的天然产物已被分离和鉴定,这为在分子水平上深入研究生物传播机制提供了重要的基础。然而,从天然来源获得此类化合物相当困难。例如,众所周知,一些蜘蛛毒素抑制大脑中的兴奋神经传递,并且是研究这种传递机制的合适工具。由于不可能从天然来源获得这些毒素的纯形式,因此它们的合成需要充足的供应。Irie和他的同事(长崎大学和北海道大学)已经完成了一种新的方法来合成这些毒素,使用叠氮基代替氨基来构建毒素中的多胺侧链。这种方法使得大量毒素的供应成为可能。Tkahashi(东京工业大学)开发了一种新的方法,可用于合成一些生物活性的聚蔗糖链。藤井(京都大学)合成了一些多肽,有可能开发新的抗艾滋病药物。上村(静冈大学)研究了海洋贝壳产生的有毒物质,并阐明了具有设计新药可能性的毒素的结构。该项目的所有成员都进行了高水平的研究工作,在国际科学期刊上发表了大量的报告。
项目成果
期刊论文数量(97)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
N.Watanabe: "Asymmetric Creation of Quaternary Carbon Centers by Enantiotopically Selective Aromatic C-H Insertion Catalyzed by Chiral Dirhodium (II)Carboxylates" Tetrahedron Lett.36. 1491-1494 (1994)
N.Watanabe:“通过手性二铑 (II) 羧酸盐催化的对映选择性芳香族 C-H 插入形成季碳中心的不对称”四面体 Lett.36。
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- 影响因子:0
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- 通讯作者:
J.Maruyama: "Synthesis of(±)-Pinoresinol and its Related Compound using Potassium Persulfate(K_2S_2O_8)Oxidation of Benzoylacetate" Heterocycles. 37. 839-845 (1994)
J. Maruyama:“使用过硫酸钾 (K_2S_2O_8) 氧化苯甲酰乙酸合成 (±)-松树脂及其相关化合物”杂环。 37. 839-845 (1994)
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- 影响因子:0
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J.Maruyama, M.Kobayashi, M.Miyashita, I.Kouno, and H.Irie: "Synthesis of (<plus-minus>) -Pinoresinol and its Related Compound using Potassium Persulfate (K_2S_2O_8) Oxidation of Benzoylacetates" Heterocycles. 37. 839-845 (1994)
J.Maruyama、M.Kobayashi、M.Miyashita、I.Kouno 和 H.Irie:“使用过硫酸钾 (K_2S_2O_8) 氧化苯甲酰乙酸酯合成 (<plus-minus>)-松脂醇及其相关化合物”杂环。
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S.Hatakeyama, K.Kojima, H.Fukuyama, and H.Irie: "An Enatioselective Synthesis of (11R,12S,13S,9Z,15Z) -9,12,13-Trihydroxyoctadeca-9,15-dienoic Acid, a Self-defensive Substance against Rice Blast Disease" Chemistry Letters. 763-764 (1995)
S.Hatakeyama、K.Kojima、H.Fukuyama 和 H.Irie:“(11R,12S,13S,9Z,15Z)-9,12,13-三羟基十八-9,15-二烯酸的对映选择性合成,
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- 影响因子:0
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S.Hatakeyama: "Enantiospecific Synthesis of (+)-Paeonilactone C nad (+)-Paeoniflorigenone from R-(-)-Carvone" Tetrahedron Lett.35. 7993-7996 (1994)
S.Hatakeyama:“从 R-(-)-香芹酮中合成 ( )-芍药内酯 C 和 ( )-芍药酮”四面体 Lett.35。
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IRIE Hiroshi其他文献
IRIE Hiroshi的其他文献
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{{ truncateString('IRIE Hiroshi', 18)}}的其他基金
Engineering of a novel oral herpesvirus vaccine using a gene therapy
使用基因疗法设计新型口服疱疹病毒疫苗
- 批准号:
09670238 - 财政年份:1997
- 资助金额:
$ 7.17万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Synthetic Studies on Spider Toxins and Their Congeners and Their Biological Activities
蜘蛛毒素及其同源物的合成及其生物活性研究
- 批准号:
04557100 - 财政年份:1992
- 资助金额:
$ 7.17万 - 项目类别:
Grant-in-Aid for Developmental Scientific Research (B)
Synthetic Studies of Gloeosporone, A Self-Inhibitor for Germination of Spores of Colletotrichum gloeosporioides
胶孢炭疽菌孢子萌发自抑制剂Gloeosporone的合成研究
- 批准号:
63570997 - 财政年份:1988
- 资助金额:
$ 7.17万 - 项目类别:
Grant-in-Aid for General Scientific Research (C)
Chemical Studies on the Substances Concerning Plants and Plant Pathogenic Fungi
植物及植物病原真菌相关物质的化学研究
- 批准号:
63303013 - 财政年份:1988
- 资助金额:
$ 7.17万 - 项目类别:
Grant-in-Aid for Co-operative Research (A)
Synthesis of the Host-specific Toxins, AK- and AF-toxin
宿主特异性毒素 AK 和 AF 毒素的合成
- 批准号:
61571007 - 财政年份:1986
- 资助金额:
$ 7.17万 - 项目类别:
Grant-in-Aid for General Scientific Research (C)
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