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Joint study on the standardization of laboratory rats

实验大鼠标准化联合研究

基本信息

批准号：
06044242
负责人：
KATOH Hideki
金额：
$ 6.14万
依托单位：
Central Institute for Experimental Animals
依托单位国家：
日本
项目类别：
Grant-in-Aid for international Scientific Research
财政年份：
1994
资助国家：
日本
起止时间：
1994 至 1996
项目状态：
已结题

项目摘要

International Rat Genetic Nomenclature Committee (RGNC) were re-established under the auspicies of the ICLAS (International Council for Laboratory Animals Science) to activate the committee activity and the 1st and 2nd committee meetings were held in Sapporo (Japan) in 1994 and in Toulouse (France) in 1996, respectively. The results obtained are summarized as follows.(1) Five sub-committees were established to help and develop the committee's activities.a. Inbred strainsb. PCR monitoringc. Rat genomics : gene symbols, DNA symbols, chromosomesd. MHC genetics : genes, symbols, recombinantse. Rat Genome(2) Rules of nomenclature of inbred strains and outbred stocks, gene loci, MHC (major histocompatibility complex) region were discussed and enforced.(3) PCR monitoring system was newly developed for genetic monitoring by the PCR monitoring committee.(4) The official journal of the committee were changed from Rat News Letter to Rat Genome and six volumes were published for three years from 1994.2. Information exchange system was established using the Internet of communicate smoothly among committee members.3. Research and development of cryopreservation techniques for the rat were carried out. Rat strains maintained in University of Pittsburgh School of Medicine as the international reference strains for immunogenetics and transplantation studies were introduced to the Central Institute for Experimental Animals and preserved in the ICLAS Embryo Bank.4. Microbiological cleaning of the reference strains maintained in University of Pittsburgh School of Medicine was carried out.

国际实验动物科学理事会（ICLAS）的支持下重新成立了国际大鼠遗传命名委员会（RGNC），并于1994年和1996年分别在日本的札幌和法国的图卢兹举行了第一次和第二次委员会会议。所得结果总结如下。(1)成立了五个小组委员会来帮助和发展委员会的活动。近交系b. PCR监测c.大鼠基因组学：基因符号，DNA符号，染色体。MHC遗传学：基因，符号，重组。（2）讨论了近交系和远交系的命名规则、基因位点、主要组织相容性复合体（MHC）区域。(3)PCR监测系统是PCR监测委员会为进行基因监测而新开发的。(4)该委员会的官方期刊从Rat News Letter改为Rat Genome，并从1994年起连续三年出版六卷。利用互联网建立了信息交流系统，使委员会成员之间的交流顺畅.开展了大鼠冷冻保存技术的研究和开发。将匹兹堡大学医学院保存的大鼠品系作为免疫遗传学和移植研究的国际参考品系引入中央实验动物研究所，并保存在ICLAS胚胎库中。对匹兹堡大学医学院保存的参考菌株进行微生物清洁。