Role of intracellular renin and (pro)renin receptor in cardiac myocytes

细胞内肾素和肾素原受体在心肌细胞中的作用

• 批准号: 23591036
• 负责人: KATOH Hideki
• 金额: $ 3.24万
• 依托单位: Hamamatsu University School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591036/
• 关键词: レニン; 糖尿病; ミトコンドリア; 心筋虚血; 虚血再灌流障害; ﾚﾆﾝ; ﾐﾄｺﾝﾄﾞﾘｱ; 組織ﾚﾆﾝ、ﾌﾟﾛﾚﾆﾝ

In this study, we found that expression of intracellular renin increased both in cytosol and mitochondriaduring ischemia in diabetic heart, and that increased renin protects cardiomyocytes from ischemic injury. This protective effect of renin is due to the reduction of UCP and acceleration of electron transport chain, which resulted in the prevention of mitochondrial depolarization and preservation of ATP production under ischemic stress. The cardioprotective effect of renin is independent from subsequent intracellular angiotensin II production.These results indicated that in contrast to previously reported adverse effects of circulating RAS, cytosolic renin plays an important role to protect myocytes from ischemic stress in diabetic heart.

在本研究中，我们发现糖尿病心肌缺血时细胞内和胞浆中的肾素表达均增加，并且增加的肾素对心肌细胞的缺血损伤具有保护作用。这种保护作用是由于在缺血应激条件下，肾素减少UCP和加速电子传递链，从而防止线粒体去极化和保护ATP的产生。这些结果表明，与以往报道的循环RAS的不良作用相反，胞浆肾素在糖尿病心脏缺血应激中起着重要的保护作用。

项目成果

Effects of nitric oxide on mitochondrial permeability transition pore and thiol-mediated responses in cardiac myocytes

• DOI: 10.1016/j.niox.2011.12.007
• 发表时间: 2012-02-15
• 期刊: NITRIC OXIDE-BIOLOGY AND CHEMISTRY
• 影响因子: 3.9
• 作者: Ohtani, Hayato;Katoh, Hideki;Hayashi, Hideharu
• 通讯作者: Hayashi, Hideharu

Non-secretory renin prevents ischemic injury by modulating mitochondrial function in diabetic heart.

非分泌性肾素通过调节糖尿病心脏的线粒体功能来预防缺血性损伤。

• 发表时间: 2013
• 作者: 土井晋平;安田一朗;森脇久隆;Daishi Nonaka
• 通讯作者: Daishi Nonaka

Non-secretory renin prevents ischemic injury by modulating mitochondrial function in diabetic heart

非分泌性肾素通过调节糖尿病心脏的线粒体功能来预防缺血性损伤

• 发表时间: 2013
• 作者: Nonaka D;Katoh H;Kumazawa A;Saotome M;Urushida T;Satoh H;Hayashi H.
• 通讯作者: Hayashi H.

Microtubule Disorganization Affects the Mitochondrial Permeability Transition Pore in Cardiac Myocytes

• DOI: 10.1253/circj.cj-13-1298
• 发表时间: 2014-05-01
• 期刊: CIRCULATION JOURNAL
• 影响因子: 3.3
• 作者: Kumazawa, Azumi;Katoh, Hideki;Hayashi, Hideharu
• 通讯作者: Hayashi, Hideharu

Intracellular renin prevents ischemic injury by modulating mitochondrial function in diabetic heart

细胞内肾素通过调节糖尿病心脏的线粒体功能来预防缺血性损伤

• 发表时间: 2013
• 作者: Nonaka D;Katoh H;Kumazawa A;Saotome M;Urushida T;Satoh H;Hayashi H.
• 通讯作者: Hayashi H.