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High dose rate fractionated interstitial radiation as an alternative to low dose rate continuous interstitial radiation

高剂量率分段间质辐射作为低剂量率连续间质辐射的替代方案

基本信息

批准号：
06304032
负责人：
INOUE Toshihiko
金额：
$ 7.81万
依托单位：
OSAKA UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Co-operative Research (A)
财政年份：
1994
资助国家：
日本
起止时间：
1994 至 1995
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06304032/
关键词：
HIGH DOSE RATE FRACTIONATED RADIATION LOW DOSE RATE CONTINUOUS RADIATION BRACHYTHERAPY HDR LDR 低線量率分割照射

项目摘要

To investigate the high dose rate fractionated interstitial radiation (F-HDR) as an alternative to low dose rate continuous interstitial radiation (C-LDR), following studies were carried out.1) Theoretical investigation using LQ model for the F-HDR in uneven fractionation and uneven interval was carried out. Using LQ model, Nominal standard effect was calculated for F-HDR.For late effect, 70 Gy/7 days were considered as the tolerance dose in the former studies. However, 70 Gy was the standard treatment dose, and 84 Gy was considered as the tolerance does in this study. Accoding to this change, for the tumor LQ model had the same result of the clinical data. However, for the late effect, alpha/beta must be considered as more than 3 that was used in the previous srudies.2) Biological study using colony formation assay for SQ5 cell revealed the relative biological effectiveness (HDR/LDR,RBE_<H/L>) of 0.77. Spheroid cells showed the relatively radioresistance at 37ﾟC.According to the data of the SCD50 (50% spheroid cure dose) , the RBE_<H/L> of the spheroid cells was calculated as 0.87. This value was almost the same of the clinical data of the early tongue cancer (60 Gy in F-HDR vs 70 Gy in C-LDR) . In F-HDR radiation, RBE was decided only by total dose. Modification of the total dose was not needed in the different fractionations for F-HDR.3) We carried out the randomized clinical trial of the F-HDR vs C-LDR for the patients with the early tongue cancer. patients were treated with 70 Gy/1 week in C-LDR group and with 60 Gy/10 fractions/6 days in F-HDR.Local recurrence occurred in 2 of 15 patients treated with C-LDR,and in none of 13 patients treated with F-HDR.This clinical trial also revealed that 70 Gy of the F-HDR was almost the same as 60 Gy of C-LDR.The theoretical model, biological study and clinical study showed the same results. We concluded the F-HDR is an alternative to C-LDR.

为了探讨高剂量率间隔间质辐射（F-HDR）作为低剂量率连续间质辐射（C-LDR）的替代方案，进行了以下研究。1)利用LQ模型对非均匀分馏段和非均匀段的F-HDR进行了理论研究。采用LQ模型，计算F-HDR的标称标准效应。对于晚期效应，在以前的研究中，70 Gy/7天被认为是耐受剂量。然而，70 Gy是标准治疗剂量，84 Gy被认为是本研究的耐受剂量。根据这一变化，对于肿瘤LQ模型具有与临床数据相同的结果。但是，对于后期效应，必须考虑α / β大于3，这在以前的研究中是使用的。2)利用菌落形成实验对SQ5细胞进行生物学研究，其相对生物学有效性（HDR/LDR,RBE_<H/L>）为0.77。球形细胞在37℃时表现出相对的抗辐射能力。根据SCD50（50%球体固化剂量）的数据，计算出球体细胞的RBE_<H/L>为0.87。该值与早期舌癌的临床数据几乎相同（F-HDR为60 Gy， C-LDR为70 Gy）。在F-HDR辐射中，RBE仅由总剂量决定。在F-HDR的不同分级中，不需要改变总剂量。3)我们对早期舌癌患者进行了F-HDR与C-LDR的随机临床试验。C-LDR组治疗剂量为70 Gy/1周，F-HDR组治疗剂量为60 Gy/10次/6天。15例接受C-LDR治疗的患者中有2例出现局部复发，13例接受F-HDR治疗的患者中没有出现局部复发。该临床试验还显示，70 Gy的F-HDR与60 Gy的C-LDR几乎相同。理论模型、生物学研究和临床研究均显示了相同的结果。我们得出结论，F-HDR是C-LDR的替代品。