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Development of Treatment Planning for High Dose Rate Brachytherapy using 3D-Simulation Model

使用 3D 仿真模型制定高剂量率近距离放射治疗治疗计划

基本信息

批准号：
07407027
负责人：
INOUE Toshihiko
金额：
$ 1.22万
依托单位：
Osaka University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (A)
财政年份：
1995
资助国家：
日本
起止时间：
1995 至 1996
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07407027/
关键词：
3-D MODEL INTERSTITIAL RADIATION SIMULATION OF OPERATION RADIOTHERAPY MALIGNANT TUMOR

项目摘要

3D-simulation model is made from the 3D image of CT or MRI using milling machine. 3D milling machine named ENDOPLAN was installed in 1993, and was applied for brachytherapy. There were no trial of the 3D model for brachytherapy around the world.The aim of this research is to develop the treatment planning and precise treatment technique using 3D simulation model. To deliver the high dose to the tumor, applicators for the guide of the sealed radioisotopes must be placed in the appropriate or planned position. It is easy to insert or place the applicators in the appropriate position using 3D-simulation model.To avoid the high dose for the critical organs, a spacer was placed between the applicators and the critical organs. It was easy to make an appropriate shape of spacer using the 3D-simulation model.Treatment results of the brachytherapy were influenced by the technique and experience of doctors in charge. However, using 3D-simulation model, doctors can easily obtain appropriate arrangements of the applicators and appropriate dose distribution. This precise treatment planning and technique will make the next step of the brachytherapy. Our clinical study of the high dose rate brachythrapy for malignant tumor is the leading study the world, and treatment planning using 3D-simulation model is also only unique study in the world.We are making a plan to use both of the 3D-simulation model and 3D imaging to obtain an appropriate arrangement of the applicators and dose distribution which dose not need the long clinical experience of doctors for the brachytherapy.

三维仿真模型是在铣床上由CT或MRI的三维图像生成的。1993年安装了名为ENDOPLAN的三维铣床，用于近距离放射治疗。近距离放射治疗的3D模型在国内外尚无试验，本研究的目的是利用3D模拟模型开发治疗计划和精确的治疗技术。为了将大剂量的放射性同位素输送到肿瘤，用于引导密封放射性同位素的涂抹器必须放置在适当的或计划好的位置。利用三维仿真模型可以方便地将敷贴器插入或放置在适当的位置，为了避免关键器官的高剂量，在敷贴器和关键器官之间放置了隔板。利用三维仿真模型可以方便地制作出合适的间隔器形状，近距离放射治疗的效果受主治医生的技术和经验的影响。然而，使用3D仿真模型，医生可以很容易地获得适当的喷涂器布置和适当的剂量分布。这种精确的治疗计划和技术将使近距离放射治疗进入下一步。我们的高剂量率近距离放射治疗恶性肿瘤的临床研究是世界领先的研究，而利用三维模拟模型进行治疗规划也是世界上唯一的研究。我们正在制定计划，将三维模拟模型和三维成像结合使用，以获得适当的敷贴器布置和剂量分布，而不需要医生长期的临床经验。