Development of the SQUID-CT for Functional Brain Mapping Based on a Helmet-Shaped Whole Head Magnetoencephalography System

基于头盔型全头脑磁图系统的SQUID-CT脑功能测绘开发

• 批准号: 06404050
• 负责人: MIZOI Kazuo
• 金额: $ 20.42万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (A)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06404050/
• 关键词: Magnetoencephalograpy; Electroencephalography; Functional Brain Map; SQUID; MRI; Visual Function; Auditory Function; Somatosensory Function; SQVID

In this study, we have designed a new magnetoencephalography (MEG) system as an advanced clinical diagnostic tool, as follows : First, visual and gustatory stimurators were designed so as not to produce magnetic noise. Second, stimulation and measurement parameters were carefully selected in order to minimize total measurement time of evoked magnetic fields for patients. Third, multimodal evoked responses were analyzed and compared between normal subjects and patients with intracranial structural lesions.Results are summarized as follows. For somatosensory stimuli, corresponding primary sensory cortices were indentified for not only major nerve stimuli in upper and lower extremities but also for single digit stimuli and for dorsal penile nerve stimuli. There found fine correspondence between functional localization and gyral anatomy in primary sensory cortex. For auditory stimuli, various types of interhemispheric asymmetries were revealed for both middle and late components of the evoked fields. Delayd latency of the major peaks were found in cases of temporal lobe tumors. Primary visual cortices on both hemispheres were localized using full visual-field stimuli and a two-dipole model. Patients with homonymous hemianopsia and bitemporal hemianopsia presented corresponding magnetic field patterns respectively. Gustatory evoked magnetic fields were measured in normal subjects. Abnormal slow wave of magnetic fields were also investigated in cases with ischemic lesion.These results promise further utility of MEG as clinical diagnostic tools as well as new rsearch tools of non-invasive human brain function. Development of clinical MEG system and other applications of superconducting physics will be accelerated.

在这项研究中，我们设计了一个新的脑磁图（MEG）系统作为一个先进的临床诊断工具，如下：第一，视觉和味觉刺激器的设计，以便不产生磁噪声。其次，仔细选择刺激和测量参数，以最大限度地减少患者诱发磁场的总测量时间。第三，对正常人和颅内结构性病变患者的多模态诱发反应进行了分析和比较。对于躯体感觉刺激，相应的初级感觉皮层被确定为不仅在上下肢的主要神经刺激，而且为单个手指刺激和阴茎背神经刺激。初级感觉皮层的功能定位与脑回解剖有良好的对应关系。对于听觉刺激，各种类型的半球间的不对称性，揭示了中间和后期组件的诱发领域。颞叶肿瘤的主要峰潜伏期延迟。使用全视野刺激和双偶极子模型定位两个半球的初级视觉皮层。同侧偏盲和双颞侧偏盲患者分别出现相应的磁场模式。在正常人的味觉诱发磁场进行了测量。脑磁图在缺血性脑损伤中的异常慢波也被研究，这些结果为脑磁图作为临床诊断工具和无创性脑功能研究提供了新的工具。加快发展临床脑磁图系统和超导物理学的其他应用。

项目成果

Nakasato, N.: "Cortical mapping using an MRI-linked whole head MEG system and presurgical decision making." Electroencephalogr Clin Neurophysiol. (in press). (1996)

Nakasato, N.：“使用 MRI 连接的全头 MEG 系统进行皮质绘图和术前决策。”

Ohtomo, S.: "Correspondence of anatomy and function in the human digit sensory cortex revealed by an MRI-linked whole head MEG system." Electroencephalogr Clin Neurophysiol. (in press). (1996)

Ohtomo, S.：“通过 MRI 连接的全头 MEG 系统揭示了人类手指感觉皮层的解剖结构和功能的对应性。”

Kawamura T,Nakasato N,Seki K,Kanno A,Fujita S,Fujiwara S,Yoshimoto T: "Neuromagnetic evidence of pre-and post-central cortical sources of somatosensory evoked responses" Electroencephalogr Clin Neurophysiol. (in press).

Kawamura T、Nakasato N、Seki K、Kanno A、Fujita S、Fujiwara S、Yoshimoto T：“体感诱发反应的前中央皮质源和后中央皮质源的神经磁证据”脑电学家临床神经生理学。

小野靖樹,他: "大脳感覚運動野同定におけるfunctional MRIとMEGの比較" 日本生体磁気学会誌. 7. 296-301 (1994)

Yasuki Ono 等人：“大脑感觉运动皮层识别中的功能性 MRI 和 MEG 的比较”日本生物磁学会杂志 7. 296-301 (1994)。

Otsuki T,Jokura H,Nakasato N,Yoshimoto T: "Stereotactic endoscopic resection of angiographically occult vascular malformations" Acta Neurochir. Suppl 61. 98-101 (1994)

Otsuki T，Jokura H，Nakasato N，Yoshimoto T：“血管造影隐匿性血管畸形的立体定向内镜切除术”Acta Neurochir。