Integrated analysis of language area using MEG, functional MRI and PET. -Clinical application to brain tumor surgery-

使用 MEG、功能 MRI 和 PET 进行语言区综合分析。

• 批准号: 14571296
• 负责人: MIZOI Kazuo
• 金额: $ 2.24万
• 依托单位: Akita University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14571296/
• 关键词: functional mapping; language area; magnetoencephalography; functional MRI; functional PET; brain tumor; 言語タスク

The present study was carried out to establish the functional mapping method of speech area using magnetoencephalogram (MEG), functional MRI (fMRI) and positron emission tomography (PET) and to improve the treatment results of the patients with frontal brain tumors in close vicinity to Broca area by optimum presurgical planning based on the functional mapping. 20 healthy volunteers were served as the control group. Speech areas were examined with fMRI and MEG while performing a verb generation task in a blocked paradigm design. In the fMRI study, the Broca area was identified at the left frontal hemisphere (inferior or middle frontal gyrus) in ninteen of the 20 right handed volunteers. With MEG study, left hemispheric speech dominance was determined in all cases. However, activation area was not always localized to Broca area indicating that MEG can detect speech-related brain areas activated simultaneously and sequentially.Six patients (ages 31-56 years) suffering from the left fronta … More l intracerebral tumors were examined with fMRI, MEG and PET while performing a verb generation task. All patients demonstrated left frontal activation which could be clearly located outside the tumor area and adjacent edema with varying degrees of additional right frontal activation. Based on the presurgical functional mapping, tumor resection was performed using a neuronavigation system. All three patients presenting with motor aphasia preoperatively showed improvement on the symptom after surgery. Two of the 3 patients without preexisting speech disturbance were symptom-free on the postoperative course. Remaining one patient showed transient motor aphasia postoperatively, and the symptom disappeared in about 10 days. Functional mapping was also undertaken postoperatively, and it was demonstrated that speech areas were preserved in all cases. The present study is indicating that preoperative multi-modality functional mapping of speech-related brain areas is useful for presurgical planning in the patients with frontal brain tumors close to language areas. Less

本研究旨在利用脑磁图（MEG）、功能磁共振成像（fMRI）和正电子发射断层扫描（PET）建立言语区的功能映射方法，并根据功能映射制定最佳术前计划，以提高靠近布罗卡区的额叶脑肿瘤患者的治疗效果。 20名健康志愿者作为对照组。在块范式设计中执行动词生成任务时，使用功能磁共振成像和脑磁图检查语音区域。在功能磁共振成像研究中，20 名右手志愿者中有 19 名的布罗卡区位于左额半球（额下回或中回）。通过 MEG 研究，在所有情况下都确定了左半球言语优势。然而，激活区域并不总是局限于布罗卡区，这表明 MEG 可以检测同时且顺序激活的与言语相关的大脑区域。 六名患有左额叶脑肿瘤的患者（年龄 31-56 岁）在执行动词生成任务时使用 fMRI、MEG 和 PET 检查。所有患者均表现出左额叶激活，可以清楚地定位在肿瘤区域和邻近水肿区域之外，并具有不同程度的额外右额叶激活。根据术前功能映射，使用神经导航系统进行肿瘤切除。所有三名术前出现运动性失语症的患者术后症状均有所改善。 3 名先前没有语言障碍的患者中有 2 名在术后过程中没有出现任何症状。其余1例患者术后出现短暂性运动性失语，10天左右症状消失。术后还进行了功能映射，结果表明所有病例中言语区域均得到保留。本研究表明，术前言语相关脑区的多模态功能映射对于靠近语言区的额叶脑肿瘤患者的术前规划很有用。较少的

项目成果

太田 徹, 東山巨樹, 木内博之, 溝井和夫: "脳磁図の臨床応用:視覚誘発脳磁界の術前・術後比較を行った後頭葉病変の2例"秋田医学. 30. 43-49 (2003)

Toru Ota、K. Higashiyama、Hiroyuki Kiuchi、Kazuo Mizoi：“脑磁图的临床应用：枕叶病变的两例以及视觉诱发脑磁场的术前和术后比较”秋田医学科学 30. 43-49 (2003)。

Ohta T, Higashiyama N, Kinouchi H, Mizoi K: "Clinical application of magnetoencephalograpy : pre and postoperative VEF study in two cases of occipital lobe lesions"Akita J Med.. 30(1). 43-49 (2003)

Ohta T、Higashiyama N、Kinouchi H、Mizoi K：“脑磁图的临床应用：两例枕叶病变的术前和术后 VEF 研究”Akita J Med. 30（1）。

太田徹, 東山巨樹, 木内博之, 溝井和夫: "脳磁図の臨床応用:視覚誘発脳磁界の術前・術後比較を行った後頭葉病変の2例"秋田医学. 30・1. 43-49 (2003)

Toru Ota、Kiyoshi Higashiyama、Hiroyuki Kiuchi、Kazuo Mizoi：“脑磁图的临床应用：枕叶病变的术前和术后视觉诱发脑磁场的比较”秋田医学科学 30・1（2003）。