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Development of the multimodal neuronavigation system integrating structural and functional information in combination with intra-operative ultrasound imaging.

开发结合结构和功能信息并结合术中超声成像的多模态神经导航系统。

基本信息

批准号：
18591573
负责人：
MIZOI Kazuo
金额：
$ 2.45万
依托单位：
Akita University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2006
资助国家：
日本
起止时间：
2006 至 2007
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18591573/
关键词：
Neurosurgery Neuronavigation brain function brain metabolism maanetoencephalography ultrasound brain tumor 脳神経疾患

项目摘要

The aims of this study were: 1) To improve the usefulness of neuronavigation system by integrating not only preoperative MRI but also three-dimensional (3-D) multimodal information of brain metabolism, brain functional mapping, and diffusion tensor imaging (DT1). 2) To develop a correction method for automatic brain shift of preoperative MRI data using intra-operative 3-D ultrasound.In this study, it was a significant result that the magnetoencephalography (MEG) mapping technique of language specific cortical areas had been established by using minimum L1 norm current estimate (MCE). When functional mapping data of MEG was compared with f-MRI, the comparable results were obtained in the determination of Broca area. Moreover, MEG was able to display a sequential activation of language specific areas other than Broca area in animation, and was more useful for an individual language field analysis.Furthermore, the integrating technique of diffusion tensor imaging (DTI) into neuronavigatio … More n system was developed. DTI was obtained using diffusion TENSOR Visualizer (Y Masutani, Tokyo University). For visualizing the pyramidal tracts, activated dusters from motor experiments provided one ROI to be traversed, together with the posterior horn of the internal capsule and the pyramid of the brain stem. The tracts were co-registered and overlaid on the contrast-enhanced T1-weighted images.In addition, the integrating technique of intra-operative ultrasound (US) images into neuronavigation system was developed. Real time evaluation of intra-operative brain shift became possible by overlaying preoperative MRI with US image on the neuronavigation monitor screen.Ten right-handed patients with left frontal brain tumors adjacent to Broca area underwent surgery using these technologies. 3-D information of the language area and the pyramidal tract were displayed on the screen of the neuronavigation system. After the craniotomy, but before opening the dura, one or more 3D ultrasound acquisitions were performed as the control US image. Tumor tissue was then removed, and additional US data were acquired for real time evaluation of brain shift. For resection control, a final US scan was acquired at the end of the operation so that complete removal of the tumor could be verified.From this study, it was shown that the multimodal neuronavigation system integrating structural and functional information in combination with intra-operative 3D US is a powerful tool for accurate, safe and efficient neurosurgical resections. Less

本研究的目的是：1）通过整合术前 MRI 以及脑代谢的三维 (3-D) 多模态信息、脑功能图和扩散张量成像 (DT1) 来提高神经导航系统的实用性。 2）开发一种使用术中3D超声对术前MRI数据进行自动脑移位的校正方法。在本研究中，一个重要的成果是利用最小L1规范电流估计（MCE）建立了语言特定皮层区域的脑磁图（MEG）映射技术。当MEG的功能图数据与f-MRI进行比较时，在确定Broca面积时获得了可比较的结果。此外，MEG能够在动画中显示除布罗卡区以外的语言特定区域的顺序激活，对于个体语言场分析更有用。此外，还开发了将扩散张量成像（DTI）集成到神经导航系统中的技术。 DTI 是使用扩散 TENSOR Visualizer（Y Masutani，东京大学）获得的。为了可视化锥体束，运动实验中激活的除尘器提供了一个要遍历的 ROI，以及内囊后角和脑干金字塔。这些束被共同配准并叠加在对比增强的T1加权图像上。此外，还开发了将术中超声（US）图像集成到神经导航系统中的技术。通过将术前 MRI 与超声图像叠加在神经导航监视器屏幕上，可以对术中脑移位进行实时评估。 10 名左利手患者，患有邻近布罗卡区的左额脑肿瘤，使用这些技术接受了手术。语言区和锥体束的 3D 信息显示在神经导航系统的屏幕上。在开颅手术之后，但在打开硬脑膜之前，进行了一个或多个 3D 超声采集作为对照 US 图像。然后去除肿瘤组织，并获取额外的美国数据以实时评估脑转移。对于切除控制，在手术结束时获得最终的超声扫描，以便验证肿瘤的完全切除。本研究表明，集成结构和功能信息的多模态神经导航系统与术中3D超声相结合是准确、安全和高效的神经外科切除的有力工具。较少的