Studies on adjuvant therapies for prevention of hepatic matastasis after resection of pancreatic cancer

胰腺癌患者的术后病程不充分，因为肝转移的频繁表现。手术与辅助治疗相结合是改善预后的唯一途径，但并发症和死亡率可能增加。为了阐明胰腺癌切除术（PD）的安全性，当放射治疗，和/或肝转移的分子机制，以下问题进行了分析。(1)由于猴排泄道的解剖结构与人类相似，因此，猴PD是了解和评价术前、术中和术后放射治疗影响的有用模型。我们建立了猴的标准PD技术。(2)临床上对PD患者术前应用曲美双酮进行肝功能测定。(3)为探讨胰腺癌肝转移的分子机制，对28例原发性胰腺癌及其中16例肝转移灶进行了E-cad和alpha-catenin蛋白表达的检测。我们发现E-cad和alpha-cat表达的状态没有显著的预测价值，即使对于具有这种细胞-细胞相互作用系统完整性的病例似乎有更高的肝转移倾向。

Postoperative course of the patient with Pancreatic carcinoma is in sufficient, because of the frequent presentation of liver metastasis. Combination of operation and adjuband therapy is only the way for improving the prognosis, however, morbidity and mortality rate may increase. In order to clarify the safes of pancreatico duodenectomy (PD), when radiation therapy is added, and/or the molecular mechanisms of liver metastasis, following issues were analyzed. (1) Because anatomy of eliminatory tract of monkey is similar to those of human, PD for monkey should be a useful model to know and evaluate the in fluence of pre-, intea- and post-operative radiation therapy. We have established the standard PD technique for monkey. (2) We clinically applied liver function assay test, using Trimethadione, for the preoperative patient of PD.(3) Intending to know the molecular mechanisms of liver metastasis, twenty-eight primary pancreatic carcinomas and liver metastatic nodules from 16 or them were analyzed for E-cadherin (E-cad) and alpha-catenin (alpha-cat) protein expression. We found that the status of the E-cad and alpha-cat expression has no significant predictive value, even though there seem to be a higher tendency to liver metastasis for cases with integrity of such cell-cell interaction system.