Development of Novel Catalyst System for Highly Enantioselective Hydroformylations and Its Application for the Syntheses of Biologically Active Compounds.
高对映选择性加氢甲酰化新型催化剂体系的开发及其在生物活性化合物合成中的应用。
基本信息
- 批准号:06555272
- 负责人:
- 金额:$ 6.59万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Developmental Scientific Research (B)
- 财政年份:1994
- 资助国家:日本
- 起止时间:1994 至 1995
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
(1) Asymmetric hydroformylation of sulfur-containing olefins, such as vinyl-and allyl-sulfide, sulfoxide, sulfones has been performed in high enantioselectivities by using a rhodium complex of chiral phosphine-phosphite, (R,S) -BINAPHOS.The resulting oxo-aldehydes have potential use as synthetic intermediates for various biologically active compounds.(2) Asymmetric hydroformylation of conjugated dienes have also been examined. There are four carbons in the dienes which are capable to be attached to the formyl group. For various diences, the present system chooses one of the four possibilities, in high enantioselectivities.(3) Highly enantioselective copolymerization of propene and carbon monoxide has been performed by using Pd (II) - (R,S) -BINAPHOS.The catalyst system produces poly (alt-propene-CD) of the highest molecular weight as well as in the highest enantioselectivity ever reported. The reaction mechanism was also investigated by NMR studies.
(1)用手性膦亚磷酸酯铑配合物(R,S)-BINAPHOS对乙烯基硫醚、烯丙基硫醚、亚砜、砜等含硫烯烃进行不对称氢化反应,得到的羰基醛具有潜在的生物活性化合物合成中间体的价值。(2)还研究了共轭二烯的不对称加氢。在二烯中有四个碳原子能够连接到甲酰基上。对于不同的双映体,本系统选择四种可能性之一,在高的对映体选择性。(3)用Pd(II)-(R,S)-BINAPHOS催化剂进行了丙烯和一氧化碳的高对映选择性共聚合,得到了分子量和对映选择性最高的聚(alt-propene-CD)。通过核磁共振研究了反应机理。
项目成果
期刊论文数量(20)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
H.Takaya: "Highly Enantioselective Hydrogenation of α,β-Unsaturated Carboxylic Acids Catalyzed by H_8-BINAP-Ru(II)Complexes" Synlett. 501-503 (1994)
H. Takaya:“H_8-BINAP-Ru(II) 配合物催化的 α,β-不饱和羧酸的高度对映选择性氢化”Synlett 501-503 (1994)。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
T.Higashijima: "Synthesis of New Chiral Phosphinephosphites Having 2-Diphenylphosphinobiphenyl-2'-yl Backborne and Their Use in Ph (I) -Catalyzed Asymmetric Hydroformylations." Tetrahedron Lett.35. 2023-2026 (1994)
T.Higashijima:“具有 2-二苯基膦联苯-2-基的新型手性膦亚磷酸酯的合成及其在 Ph (I) 催化的不对称加氢甲酰化中的应用。”
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
T.Nanno: "Asymmetric Hydroformylation of Sulfur-Containing Olefins Catalyzed by BINAPHOS-Rh (I) Complexes." Tetrahedron : Asymmetry. 6. 2583-2591 (1995)
T.Nanno:“BINAPHOS-Rh (I) 配合物催化的含硫烯烃的不对称氢甲酰化。”
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
H.Takaya: "Enantioselcetive Hydrogenation of Acyclic Aromatic Ketones Catalyzed by BINAP-Ir(I)-Aminophosphine Systems" Tetrahedron:Asymmitry. 5. 1179-1182 (1994)
H.Takaya:“BINAP-Ir(I)-氨基膦体系催化的无环芳香酮的对映选择性氢化”四面体:不对称。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
N. Sakai: "Asymmetric Hydroformylation of 1,2-Disubstituted Olefins Catalyzed by Chiral Phosphinephosphite-Rh(I)Complexes." J. Chem. Soc., Chem. Commun.395-396 (1994)
N. Sakai:“手性膦亚磷酸盐-Rh(I)复合物催化的 1,2-二取代烯烃的不对称加氢甲酰化。”
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- 发表时间:
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- 影响因子:0
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NOZAKI Kyoko其他文献
NOZAKI Kyoko的其他文献
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{{ truncateString('NOZAKI Kyoko', 18)}}的其他基金
Cultural Transition in Asian immigrant Communities in the United States in Asian American Literature
亚裔美国文学中美国亚裔移民社区的文化变迁
- 批准号:
19520271 - 财政年份:2007
- 资助金额:
$ 6.59万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Synthesis of Highly Stereoregular Polymers Utilizing Carbon Dioxide as a Comonomer
利用二氧化碳作为共聚单体合成高立构聚合物
- 批准号:
17065005 - 财政年份:2005
- 资助金额:
$ 6.59万 - 项目类别:
Grant-in-Aid for Scientific Research on Priority Areas
Functions Realized by Controlled Configuration of Optically active Polymers
通过光学活性聚合物的受控构型实现的功能
- 批准号:
14550835 - 财政年份:2002
- 资助金额:
$ 6.59万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Precise Synthesis of Functional Polymers Utilizing Cl Resources.
利用Cl资源精确合成功能聚合物。
- 批准号:
12650866 - 财政年份:2000
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$ 6.59万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Chiral Lewis Acids with Two Boron Centers
具有两个硼中心的手性路易斯酸
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08651006 - 财政年份:1996
- 资助金额:
$ 6.59万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
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