Development of novel medicine for stimulating gastrointestinal function based on analysis of food recognition system

基于食物识别系统分析的刺激胃肠功能新药的开发

• 批准号: 06556021
• 负责人: FUSHIKI Tohru
• 金额: $ 2.94万
• 依托单位: KYOTO UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Developmental Scientific Research (B)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06556021/
• 关键词: Cholecystokinin; Fatty acid; Recognition; IEC-6; 消化管; 膵酵素分泌; 食物認識; 消化・吸収促進

Fatty acids are common stimulators of the release of almost all gastrointestinal peptides in the small intestine. In enteroendocrine cells, fatty acids increase intracellular calcium levels. Linoleic acid and oleic acid markedly increased the influx of calcium into small intestinal cells and the small intestinal cell line (IEC-6). By contrast, octanoic acid, methyl linoleate, and linolyl alchol had no effect on the influx. Acidic amino acids and methyl linoleate inhibited the linoleic acid-induced influx of calcium, indicating that activation of the influx by linoleic acid depended on the chain length and was affected by the presence of a carboxyl group. Of the gastrointestinal hormones, somatostatin specifically inhibited the linoleic acid-induced influx of calcium.

脂肪酸是小肠中几乎所有胃肠道多肽释放的常见刺激物。在肠道内分泌细胞中，脂肪酸会增加细胞内的钙水平。亚油酸和油酸显著增加小肠细胞和小肠细胞系(IEC-6)的钙内流。相比之下，辛酸、亚油酸甲酯和芳樟醇对内流没有影响。酸性氨基酸和亚油酸甲酯抑制亚油酸诱导的钙内流，表明亚油酸对钙内流的激活依赖于链长，并受羧基的影响。在胃肠激素中，生长抑素特异性地抑制亚油酸诱导的钙内流。

项目成果

T. Shintaniら: "Recognition system for dietary fatty acids in the rat small intestine" Biosci. Biotech. Biochem.59. 1428-1432 (1995)

T. Shintani 等人：“大鼠小肠中膳食脂肪酸的识别系统”Biosci.59（1995）。

T. Sintaniら: "The recognition system of dietary fatty acids by the rat small intestinal cells" Biosci Biotech. Biochem.59. 479-481 (1995)

T. Sintani 等人：“大鼠小肠细胞的膳食脂肪酸识别系统”Biosci Biochem.599-481 (1995)。

T.Shintani et al.: "Recognition system for dietary fatty acids in the rat small intestine" Biosci.Biotech.Biochem.59. 1428-1432 (1995)

T.Shintani 等人：“大鼠小肠膳食脂肪酸的识别系统”Biosci.Biotech.Biochem.59。

T. Sintani ら: "The recognition system of dietary fatty acid by the rat small intestinal cells." Biosci. Biotech. Biochem.59. 479-481 (1995)

T. Sintani 等人：“大鼠小肠细胞的膳食脂肪酸识别系统。Biosci。59-481 (1995)。

T.Shintani et al.: "The recognition system of dietary fatty acids by the rat small intestinal cells." Biosci.Biotech.Biochem.59. 479-481 (1995)

T.Shintani 等人：“大鼠小肠细胞对膳食脂肪酸的识别系统。”