Development of novel medicine for stimulating gastrointestinal function based on analysis of food recognition system

脂肪酸是小肠中几乎所有胃肠肽释放的常见刺激物。在肠内分泌细胞中，脂肪酸增加细胞内钙水平。亚油酸和油酸显著增加小肠细胞和小肠细胞系（IEC-6）的钙内流。相比之下，辛酸，亚油酸甲酯，亚油酸和亚麻醇没有影响的流入。酸性氨基酸和亚油酸甲酯抑制亚油酸诱导的钙内流，表明亚油酸的内流激活依赖于链长，并受到羧基的存在下。在胃肠激素中，生长抑素特异性地抑制亚油酸诱导的钙内流。

Fatty acids are common stimulators of the release of almost all gastrointestinal peptides in the small intestine. In enteroendocrine cells, fatty acids increase intracellular calcium levels. Linoleic acid and oleic acid markedly increased the influx of calcium into small intestinal cells and the small intestinal cell line (IEC-6). By contrast, octanoic acid, methyl linoleate, and linolyl alchol had no effect on the influx. Acidic amino acids and methyl linoleate inhibited the linoleic acid-induced influx of calcium, indicating that activation of the influx by linoleic acid depended on the chain length and was affected by the presence of a carboxyl group. Of the gastrointestinal hormones, somatostatin specifically inhibited the linoleic acid-induced influx of calcium.