Basic study on developments of foods having a function that, enhances endurance capacity

为评价小鼠的耐力能力，设计了一种新的测定小鼠最大游泳时间的强迫游泳装置。不同饮食和药物治疗后的小鼠。在游泳池中，利用水泵循环水产生的水流。喷嘴和吸缝被设计成产生恒定的电流，而电流的强度由阀门调节。随着电流速度的增加，小鼠踢腿时间缩短，证实了工作负荷可以通过电流速度的调节来调节。在这个装置中，当比较踢腿间隔和前腿划桨间隔时，小鼠使用最多的是后腿。在两个品系的小鼠中，证实了直到疲劳的游泳时间随着水流速度的增加而减少。作为生化指标，血乳酸和肌糖原水平证实了电流速度与工作负荷增加之间的相关性。这些结果表明，本研究中使用的仪器在评价小鼠的耐力方面具有许多优点，并可用于检测饮食和药物对耐力的影响。

A new forced swimming apparatus for determining maximum swimming time in mice was devised for use in evaluations of the endurance capacity. of mice following various treatments with diet and drugs. A water current generated by circulating water with a pump was developed in a swimming pool. A spout and suction slit were contrived to generate a constant current while the strength of the current was regulated by a valve. The decrease of the leg kicking intervals of mice accompanying increase in the current speed was confirmation that the work load is adjustable by regulation of current speed. The hind legs were most used by mice in this apparatus when compared the kicking intervals to forelegs paddling intervals. That swimming time until fatigue was decreased with relationship to increasing current speed was confirmed in two strains of mice. As biochemical indexes, blood lactate and muscle glycogen levels corroborated the correlation between current speed and increase in work load. These results indicate that the apparatus employed in the present study offers many advantages in the evaluation of the endurance capacity of mice, and is useful for detecting the effects of diets and drugs on this capacity.