Advancing the visualisation and quantification of nephrons with MRI.

利用 MRI 推进肾单位的可视化和量化。

• 批准号: DP220102042
• 负责人: Prof David Reutens
• 金额: $ 35.02万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-06-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP220102042
• 关键词: Advancing; visualisation; quantification; nephrons; MRI.

This project aims to characterise key components of nephrons, the glomeruli and tubules, using magnetic resonance imaging without contrast agents, in combination with Deep Learning and super-resolution techniques. Nephrons, the basic functional unit of the kidney, are critical to the maintenance of the body’s homeostasis. Their number and architecture are critical determinants of kidney function. The expected outcomes are innovative semi-automated nephron visualisation and quantitation tools that enable efficient renal phenotyping. Techniques tailored to widely accessible preclinical research scanners are expected to accelerate research into genetic and environmental factors affecting kidney microstructure in embryonic and post-natal life.

该项目旨在使用无造影剂的磁共振成像，结合深度学习和超分辨率技术，对肾单位，肾小球和肾小管的关键组成部分进行分析。肾单位是肾脏的基本功能单位，对维持身体的稳态至关重要。它们的数量和结构是肾功能的关键决定因素。预期的成果是创新的半自动肾单位可视化和定量工具，使有效的肾脏表型。为广泛使用的临床前研究扫描仪量身定制的技术有望加速对影响胚胎和出生后肾脏微观结构的遗传和环境因素的研究。