Towards direct imaging of neuronal currents with MRI

利用 MRI 对神经元电流进行直接成像

• 批准号: DP150104771
• 负责人: Prof David Reutens
• 金额: $ 31.27万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2018-12-15
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP150104771
• 关键词: Towards; direct; imaging; neuronal; currents

This project aims to develop novel neuronal current magnetic resonance imaging (nc-MRI) methods that harness the oscillatory behaviour of neuronal magnetic fields. Current methods of detecting neuronal activity in the living human brain have limited spatial and temporal resolution. Use of nc-MRI aims to overcome these limitations by imaging the effects on the MRI signal of small transient magnetic fields associated with neuronal activity. Signal-to-noise ratio is at the limits of detectability using current imaging systems and nc-MRI is yet to be convincingly demonstrated. An integrated framework for simulating nc-MRI in the visual cortex is expected to be developed.

该项目旨在开发新的神经元电流磁共振成像（nc-MRI）方法，利用神经元磁场的振荡行为。目前检测活体人脑中神经元活动的方法具有有限的空间和时间分辨率。使用nc-MRI旨在通过成像与神经元活动相关的小瞬态磁场对MRI信号的影响来克服这些限制。使用当前成像系统的信噪比处于可检测性的极限，nc-MRI尚未得到令人信服的证明。预计将开发一个用于模拟视皮质nc-MRI的集成框架。