Revealing the mechanobiology of neural tube formation

揭示神经管形成的力学生物学

• 批准号: DP220101878
• 负责人: Dr Melanie White
• 金额: $ 33.08万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-06-20 至 2025-06-19
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP220101878
• 关键词: Revealing; mechanobiology; neural; tube; formation

This project aims to understand the formation of the neural tube; a fundamental tissue structure that generates the brain and the spinal cord. Using interdisciplinary approaches and exploiting recent advances in transgenic and imaging technologies, we expect to reveal the complex interplay between cells and their environment that generates mechanical forces to direct neural tissue formation. Outcomes include knowledge of previously intractable developmental processes, training of future scientists and development of international collaborations. This should provide enhanced imaging capacity, a higher quality scientific workforce and position Australia at the forefront of cell and developmental biology.

该项目旨在了解神经管的形成;神经管是产生大脑和脊髓的基本组织结构。使用跨学科的方法，并利用转基因和成像技术的最新进展，我们希望揭示细胞及其环境之间的复杂相互作用，产生机械力来指导神经组织的形成。成果包括以前棘手的发展过程的知识，未来的科学家的培训和国际合作的发展。这将提供更强的成像能力，更高质量的科学工作队伍，并将澳大利亚置于细胞和发育生物学的前沿。