Regulation of activity-induced glutamate receptor trafficking in neurons

神经元中活动诱导的谷氨酸受体运输的调节

• 批准号: DP220101645
• 负责人: A/Prof Victor Anggono
• 金额: $ 38.83万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP220101645
• 关键词: Regulation; activity; induced; glutamate; receptor

Neurons communicate via synapses, where chemicals (such as glutamate) are released to transmit neuronal signals. This proposal is aimed at understanding the molecular mechanisms of neuronal communication and adaptive plasticity, which are essential for normal brain function. The proposed research will combine biophysical, biochemical, molecular and cell biological assays to elucidate the role of a calcium binding protein in controlling glutamate receptor trafficking in neurons. The outcomes will enhance our understanding of how neural plasticity is generated and maintained, knowledge that is critical for our understanding of cellular correlates of information, sensory and motor processing, as well as learning, memory and cognition.

神经元通过突触进行通信，在突触中释放化学物质(如谷氨酸)来传递神经元信号。这一建议旨在了解神经元通讯和适应性可塑性的分子机制，这是正常大脑功能所必需的。这项拟议的研究将结合生物物理、生化、分子和细胞生物学分析来阐明钙结合蛋白在控制谷氨酸受体在神经元运输中的作用。这些结果将增强我们对神经可塑性是如何产生和维持的理解，这一知识对于我们理解信息、感觉和运动处理的细胞关联以及学习、记忆和认知至关重要。