Regulation of glutamate receptor dynamics in mammalian central neurons

哺乳动物中枢神经元谷氨酸受体动力学的调节

• 批准号: DP190101390
• 负责人: A/Prof Victor Anggono
• 金额: $ 35.7万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-05-21 至 2022-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP190101390
• 关键词: Regulation; glutamate; receptor; dynamics; mammalian

This proposal aims to understand the molecular mechanisms of neuronal communication and how neurons modify their synaptic strength. Although these processes are essential for normal brain function, the precise underlying mechanisms are still not well understood. This project will combine biochemical, molecular and cell biological assays, as well as electrophysiological measurements, to provide mechanistic insights into the molecular processes that control glutamate receptor trafficking in the postsynaptic compartment. This will elucidate how neural plasticity is generated and maintained, information that is critical for our understanding of sensory processing, learning and memory throughout life.

该提案旨在了解神经元通信的分子机制以及神经元如何修改其突触强度。虽然这些过程对正常的大脑功能至关重要，但确切的潜在机制仍然没有得到很好的理解。该项目将结合联合收割机生物化学，分子和细胞生物学检测，以及电生理测量，以提供控制谷氨酸受体在突触后区室运输的分子过程的机理见解。这将阐明神经可塑性是如何产生和维持的，这些信息对于我们理解整个生命中的感觉处理，学习和记忆至关重要。