How membrane-sensing proteins regulate synaptic vesicle endocytosis

膜传感蛋白如何调节突触小泡内吞作用

• 批准号: DP170102402
• 负责人: A/Prof Victor Anggono
• 金额: $ 29.24万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP170102402
• 关键词: How; membrane; sensing; proteins; regulate

This project aims to elucidate the molecular basis of how membrane-sensing proteins regulate synaptic vesicle endocytosis in mammalian central neurons. Nerve cells’ ability to transmit cellular information to one another is important for normal brain function. Efficient communication between neurons through sustained neurotransmitter release relies on the continuous supply of synaptic vesicles in presynaptic nerve terminals. Key to this process are membrane dynamics during synaptic vesicle retrieval, but the precise underlying mechanisms are not well understood. The intended outcome of this project is insights into the molecular mechanisms of synaptic transmission, the fundamental process of brain function, increasing understanding of physiological processes such as muscle movement, vision, hearing, touch, learning and memory.

本项目旨在阐明膜敏感蛋白如何调节哺乳动物中枢神经元突触囊泡内吞作用的分子基础。神经细胞相互传递细胞信息的能力对正常的大脑功能很重要。神经元之间通过持续的神经递质释放进行的有效通信依赖于突触前神经末梢中突触囊泡的持续供应。这个过程的关键是突触囊泡回收过程中的膜动力学，但确切的潜在机制还没有很好地理解。该项目的预期成果是深入了解突触传递的分子机制，大脑功能的基本过程，增加对肌肉运动，视觉，听觉，触觉，学习和记忆等生理过程的理解。