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Experimental and Clinical Study of Early MR Finding of Aseptic Necrosis of Femoral head. Utilization of the Fat Suppression Technique

股骨头无菌性坏死早期MR表现的实验与临床研究。

基本信息

批准号：
06670938
负责人：
IRIMOTO Masahiro
金额：
$ 1.22万
依托单位：
Juntendo University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1994
资助国家：
日本
起止时间：
1994 至 1996
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06670938/
关键词：
aseptic necrosis of femoral head magnetic resonance imaging systemic lupus erythemasosus steroid fat suppression imaging contrast media 一過性骨萎縮症大腿骨頭壊死症動物 MRI 脂肪抑制 Gd-DTPA

项目摘要

Steroid induced ANF (aseptic necrosis of femoral head) is one of the serious complications in the patients of SLE (systemic lupus erythemasoses).Twenty-six SLE patients with steroid therapy underwent newly developed contrast enhanced fat suppression (CEFS) MR imaging.MRI revealed ANF in nine patients. In three patients, CEFS images showed marked diffuse enhancement area in the femoral head. It was thought that this showed bone marrow edema which is supposed earliest changes of ANF. However, definite ANF did not occurred in any patient in follow up study for three years. It is considered to need to follow up furthermore in order to confirm this hypothesis. To reveal correlation between CEFS findings and pathology of the femoral head, we intended experimental study in animal model. We established CEFS imaging methods for rabbits, however the experimental induction of osteonecrosis in rabbits was not completed.CEFS imaging which was developed in this study could be used for diagnosis of other skeletal diseases such as fatigue fracture, rheumatoid arthritis and transient osteoporosis of the femoral head. We reported these results in journal and oral presentations.We improved fat suppression technique in this study. As a result, we apply this fat suppression technique for improvement of the image quality of magnetic resonance cholangiopancreatography, and reported as a result of this grant.

类固醇诱导的股骨头无菌性坏死（ANF）是系统性红斑狼疮（SLE）患者的严重并发症之一。26例接受类固醇治疗的SLE患者接受了新开发的对比增强脂肪抑制（CEFS）MR成像。MRI显示9例患者出现ANF。3例患者CEFS图像显示股骨头内有明显的弥漫性强化区。这被认为是骨髓水肿，这被认为是ANF的最早变化。随访3年，无一例患者出现明确的ANF。据认为，需要进一步采取后续行动，以证实这一假设。为了揭示CEFS所见与股骨头病理的相关性，我们拟在动物模型上进行实验研究。我们建立了兔CEFS成像方法，但尚未完成兔骨坏死的实验诱导，本研究开发的CEFS成像可用于疲劳骨折、类风湿性关节炎和股骨头短暂性骨质疏松症等其他骨骼疾病的诊断。我们在期刊和口头报告中报告了这些结果，本研究改进了脂肪抑制技术。因此，我们将这种脂肪抑制技术应用于改善磁共振胰胆管造影的图像质量，并作为该资助的结果进行了报道。