Portal embolization for hepatic cancer treatment

肝门栓塞治疗肝癌

• 批准号: 06671250
• 负责人: GOSEKI Narihide
• 金额: $ 1.41万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06671250/
• 关键词: liver cancer; hepatocellular carcinoma; portal embolization; trans arterial embolization; portal occlusion catheter; 肝切除; 肝細胞癌; 門脈塞栓術; 肝動脈塞栓術; ゲラテン; EO; 動物実験; 臨床研究

(a) To chose the suitable materials for safe and complete selective protal branch occlusion (sPBO), we made the experiments using rabbits. As a result, hydrated gelatin powder was proved to be the most suitable for the temporary portal occlusion material, because within 2 weeks no histological abnormality was remained in the hepatic tissue architecture. For the permanent occlusion, it is effective and safe to add a small amount of ethanolamin oleate after gelatin emboilization. In the liver cancer patients, we successfully accomplished intraoperative sPBO of the liver segment with cancer by administration of these materials via double balloon catheter with 4 lumens, which we had deviced, and resulted in marked decrease of intraoperative blood loss with no increase of the postoperative liver dysfunction.(b) In preoperative liver cancer patients, we tried to perform the sPBO of the cancer bearing hepatic segment after transarterioal embolization (TAE) and about 1 month after these treatments, we performed hepatectomy. All cases recovered with no serious complication. By the histological examination of the resected material, it was also demonstrated that the tumor cells were almost fallen in necrosis in cases received sPBO within 1 week after TAE.(c) In conclusion, combination treatment with TAE and sPBO within a short period should be a possible effective therapy for liver cancer.

(a)为选择安全、完整的选择性门分支阻断术（sPBO）材料，我们进行了家兔实验。结果表明，水合明胶粉最适合作为临时门静脉阻断材料，因为在2周内肝脏组织结构中没有留下任何组织学异常。对于永久性咬合，明胶冻干后加入少量油酸乙醇胺是安全有效的。在肝癌患者中，我们成功地完成了术中sPBO的肝段癌通过管理这些材料通过双球囊导管与4腔，我们已经装置，并导致术中失血量显着减少，术后肝功能不增加。(b)在术前肝癌患者中，我们尝试在经动脉栓塞（TAE）后对载癌肝段进行sPBO，并在这些治疗后约1个月进行肝切除术。所有病例均痊愈，无严重并发症。术后1周内，sPBO组肿瘤细胞几乎全部坏死。(c)总之，短期内TAE和sPBO联合治疗肝癌可能是一种有效的治疗方法。

项目成果

Narihide Goseki et al.: "Extraperitoneal Retrograde Transhepatic Biliary Drainage for Common Bile Duct Exploration for Prevention of Tube Dislodgement and its Earlier Removal" Digestive surgery. (in press). (1997)

Narihide Goseki 等人：“腹膜外逆行经肝胆道引流用于胆总管探查，以预防管移位及其早期切除”消化手术。

Narihide Goseki et al.: "Prooedures of Simultaneous Radical Resection Indicated for Primary Synchronous Esophageal and Liver Canoer-From the Personal Experience of Three Cases" Hepato-Gastroenterology. 43. 1353-1358 (1996)

Narihide Goseki 等人：“原发性同步食管癌和肝癌的同步根治性切除术——来自三个病例的个人经验”肝胃肠病学。

野坂 俊壽: "肝細胞癌と門脈血流に関する検討" 日本外科学会雑誌. 807-813 (1994)

Toshihisa Nosaka：“肝细胞癌和门静脉血流的研究”日本外科学会杂志807-813（1994）。

Narihide Goseki: "Hepatic Resection uniler the intermittent selective portal branch occhrsion by balloon catheter" Journal of The American College of Surgeons. 179. 673-678 (1994)

Narihide Goseki：“通过球囊导管间歇性选择性门静脉分支切除的肝切除术”美国外科医生学会杂志。

五関,謹秀: "Portal ooclusion balloon catheterを用いた間欠的門脈血流遮断下の肝切除" 手術. 48. 1339-1343 (1994)

Goseki, Yoshihide：“使用门静脉闭塞球囊导管进行间歇性门静脉血流闭塞下的肝切除术”，Surgery 48. 1339-1343 (1994)。