Development of physiological regional hepatic function test using positron emission tomography

正电子发射断层扫描生理性局部肝功能检测的发展

• 批准号: 06671297
• 负责人: TANIGUCHI Hiroki
• 金额: $ 1.28万
• 依托单位: Kyoto Prefectural University of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06671297/
• 关键词: Resional hepatic blood flow; Arterial hepatic blood flow; Portal hepetic blood flow; Positron emission tomography; 分肝機能検査; 肝血流量; 肝血液量

As the liver has dual blood supplies, arterial and portal, regional hepatic blood flow had not been measured quantitatively. However, we succeeded in simultaneously measuring both regional hepatic arterial and portal blood flow by PET in non-stressed patients. To examine the more accurate physiological function of the liver, a new model was designed for positron emission tomographic study using H_2^<15>O,which was consisted of the components of the liver and the portal system, applied "curve analysis", and introduced a portosystemic shunt factor and a coefficient for circulation time within the portal organs. PET scans of the liver were performed using the H_2^<15>O dynamic method in 121 patients which were classified into 4 groups ; normal, chronic hepatitis, cirrhosis and the others. They were consisted of 61,39,16, and 5 patients. Significant differences between normal and cirrhotic patients were noted in the regional total, arterial, portal hepatic blood flow, the ratio of porto-systemic shunting, and the circulating time within the portal organs for the blood. There was a significant differences between them also in a coefficient of the liver for water when positron emission tomographic scan, which was thought to be useful as a new pathophysiological parameter of the liver. Positron emission tomographic study was beneficial for the physiological regional hepatic function test.

由于肝脏具有动脉和门静脉双重血供，因此尚未对肝脏局部血流量进行定量测量。然而，我们成功地通过PET同时测量了非应激患者的局部肝动脉和门脉血流量。为了更准确地检测肝脏的生理功能，设计了一种新的用于正电子发射断层扫描研究的模型，该模型由肝脏和门脉系统的组成部分组成，应用“曲线分析”，并引入门体分流因子和门脉器官内循环时间系数。对121例患者按正常组、慢性肝炎组、肝硬变组和其他组的肝脏进行了H_2和15&GT；O动态扫描。其中61例，39例，16例，5例。正常组与肝硬化组在局部总血流量、动脉血流量、门脉肝血流量、门体分流率、门脉器官内循环时间等方面均有显著差异。两者在正电子发射断层扫描时的肝脏吸水系数也有显著差异，有望作为一种新的肝脏病理生理参数。正电子发射断层扫描有助于生理性局部肝功能检测。

项目成果

谷口 弘毅: "ポジトロンCTを用いたC^<15>O_2吸入定常法による肝局所血流量測定の意義" 薬理と治療. 24. S53-S57 (1996)

Hiroki Taniguchi：“使用正电子CT通过恒定C 15 O_2吸入法测量局部肝血流量的意义”药理学和治疗24。S53-S57(1996)。

谷口弘毅他: "肝臓の機能診断-ポジトロンCT" 肝胆膵. 29・4. 683-688 (1994)

Hiroki Taniguchi 等：“肝功能诊断 - 正电子 CT”肝胆胰 29・4（1994）。

谷口 弘毅: "肝臓の機能診断-ポジトロンCT" 肝胆膵. 29. 683-688 (1994)

Hiroki Taniguchi：“肝功能诊断 - 正电子 CT”肝胆胰。 29. 683-688 (1994)

H.Taniguchi: "Determination of the spleen-blood partition coefficient for water with 150-water dyuaunic C^<150>.steady state PET study" Journal of Nucleen Medicine. (4月掲載予定). (1995)

H.Taniguchi：“用 150-水 Dyuaunic C^<150> 测定水的脾血分配系数。稳态 PET 研究”《核医学杂志》（计划于 4 月出版）。

Hiroki Taniguchi, et al: "Simultaneous quantification of arterial and portal blood flow in the liver using H_2^<15>O-positron emission tomography." Image Technology & Information Display. 26 (8). 449-453 (1994)

Hiroki Taniguchi 等人：“使用 H_2^15O-正电子发射断层扫描同时量化肝脏中的动脉和门静脉血流。”