Research for the development of foreseeing and early diagnosis for hepatic metastasis from digestive cancer

消化道癌肝转移预见及早期诊断进展研究

• 批准号: 11671264
• 负责人: TANIGUCHI Hiroki
• 金额: $ 2.3万
• 依托单位: Kyoto Prefectural University of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11671264/
• 关键词: liver metastasis; Positron emission tomography; prediction; early diagnosis

Metastasis of the digestive cancer is very important for prognosis of the disease. In particular, the improvement of hepatic metastasis is urgently needed. However the very small metastatic lesion in the liver has been able to detect by medical imaging modalities, if smaller size of lesion is detectable, treatment effect will improve. If invisible size of hepatic metastasis is detected, complete remission will be given after chemotherapy using anti-angiogenetic drugs or anti-cancer drugs. Aim of this research is the detection of invisible metastatic lesion in the liver by detecting the blood flow change in the liver due to angiogenesis using positron emission tomography. As results,Increase in arterial blood flow and decrease in portal blood flow were detected in the liver with metastasis using animal model.Hepatic blood flow was measured in patients with advanced colorectal cancer using H_2^<15>O bolus injection dynamic positron emission tomography study as control.Hepatic blood flow was measured in patients with colorectal hepatic metastasis using H_2^<15>O bolus injection dynamic positron emission tomography study. And, increase in arterial blood flow and decrease in portal blood flow were detected in the liver.It was proved that early detection was possible by detecting the change of arterial and portal blood flow using positron emission tomography

消化道恶性肿瘤的转移是影响其预后的重要因素。特别是肝转移的改善迫在眉睫。然而，肝脏中非常小的转移性病灶已经能够通过医学成像方式检测到，如果可以检测到更小尺寸的病灶，则治疗效果将得到改善。如果检测到不可见的肝转移灶，使用抗血管生成药物或抗癌药物进行化疗后将获得完全缓解。本研究的目的是通过正电子发射断层扫描检测由于血管生成引起的肝脏血流变化来检测肝脏中不可见的转移性病变。结果显示，转移瘤动物模型肝动脉血流量增加，门静脉血流量减少，进展期结直肠癌患者肝血流量以H_2 <15>^O团注动态正电子发射断层扫描法测定，结直肠癌肝转移患者肝血流量以H_2^<15>O团注动态正电子发射断层扫描法测定。肝动脉血流量增加，门静脉血流量减少，正电子发射断层扫描检测肝动脉和门静脉血流量变化，证明早期发现肝硬化是可能的

项目成果

T.Obayashi, H.Taniguchi, T.Mugitani, T.Koh, K.Kitagawa: "Safety and utility of autologous blood transfusion for resection of metastatic liver tumor"Hepato-Gastroenterology. 48・39. 812-817 (2001)

T.Obayashi、H.Taniguchi、T.Mugitani、T.Koh、K.Kitakawa：“自体输血切除转移性肝肿瘤的安全性和实用性”肝胃肠病学 48・39（2001）。

A. Yamaguchi, H. Taniguchi, S. Kunishima, T. Koh, H. Yamagishi: "Correlation between Angiographically Assessed Vascularity and Blood Flow in Hepatic Metastases in Patients with Colorectal Carcinoma"Cancer. 89-6. 1236-1244 (2000)

A. Yamaguchi、H. Taniguchi、S. Kunishima、T. Koh、H. Yamagishi：“结直肠癌患者肝转移血管造影评估的血管分布与血流的相关性”癌症。

H. Taniguchi, S. Kunishima, T. Koh, A. Oguro, H. Yamagishi: "Reproducibility of repeated human regional splenic blood flow measurements using [^<15>O] water and positron emission tomography"Nuclear Medicine Communications. 22-7. 755-757 (2001)

H. Taniguchi、S. Kunishima、T. Koh、A. Oguro、H. Yamagishi：“使用[^ 15 O]水和正电子发射断层扫描重复人体区域脾血流测量的再现性”核医学通讯。

谷口弘毅、山口明浩、國嶋 憲、高 利守、北川一智、大林孝吉、山岸久一: "C1502吸入定常によるポジトロンCT画像の表しているものは?-H2150静注動態法による肝血流量との関連から-"薬理と治療. 27(Suppl3). 783-786 (1999)

Hiroki Taniguchi、Akihiro Yamaguchi、Ken Kunishima、Toshimaru Taka、Kazutomo Kitakawa、Kokichi Obayashi、Hisakazu Yamagishi：“稳定吸入 C1502 的正电子 CT 图像代表什么？ - H2150 静脉注射动态方法的肝血流量与 - “药理学和治疗。27（Suppl3）。783-786（1999）

山口明浩、谷口弘毅、國嶋 憲、高 利守、増山守、小山拡史、小黒厚、山岸久一: "肝硬変患者の脾腫について"薬理と治療. 27(Suppl3). 783-786 (1999)

Akihiro Yamaguchi、Hiroki Taniguchi、Ken Kunishima、Mamoru Taka、Mamoru Masuyama、Hiroshi Koyama、Atsushi Oguro、Hisakazu Yamagishi：“关于肝硬化患者的脾肿大”27（Suppl3）。