A STUDY ON THE TREATMENT FOR SEPTIC MULTIPLE ORGAN FAILURE THROUGH IMPROVEMENT OF TISSUE OXYGEN METABOLISM

改善组织氧代谢治疗脓毒症多器官衰竭的研究

基本信息

  • 批准号:
    06671506
  • 负责人:
  • 金额:
    $ 1.28万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 财政年份:
    1994
  • 资助国家:
    日本
  • 起止时间:
    1994 至 1996
  • 项目状态:
    已结题

项目摘要

This study was undertaken to investigate the treatment for septic multiple organ failure (MOF) through improvement of tissue oxygen metabolism. First, we investigated the clinically applicable methods for evaluation of tissue oxygen metabolism. Cellular injury score (CIS) measured simultaneously with oxygen delivery and oxygen consumption was a useful method to evaluate the disturbance of tissue oxygen metabolism in septic MOF patients. Gastric intramucosal pH (gastric pHi) measured by Tonometer, newly developed non-invasive device for monitoring of oxygen debt in visceral area, was also clinically useful method for early detection of the disturbance of tissue oxygen metabolism in critically ill patients. From these results, we next investigated the effective treatment for improvement of tissue oxygen metabolism in septic MOF.Hemodynamic management to achieve supranormal oxygen transport values with aggressive fluid resuscitation and catecholamine administration was carried out in patients with severe sepsis. These treatments were effective in early sepsis to improve relative tissue hypoxia and prevent organ dysfunction. However, in patients with extremely developed MOF,these treatments were failed to improve tissue oxygen metabolism, which supposed to be mainly due to decreased oxygen uptake affected by various humoral mediators in these patients. Thus, although approaches to improve tissue oxygen metabolism could be an new treatment for septic MOF,another approaches shoud be established to improve O_2 extraction as well as hemodynamic management to achieve supranormal oxygen transport values.
本研究旨在探讨通过改善组织氧代谢治疗脓毒性多器官功能衰竭(MOF)。首先,我们研究了临床上适用的组织氧代谢评价方法。细胞损伤评分(CIS)与氧供、氧耗同步测定是评价脓毒症MOF患者组织氧代谢紊乱的有效方法。应用张力计测量胃粘膜内pH(gastric pHi)是一种新开发的无创性内脏区氧债监测装置,也是临床上早期发现危重患者组织氧代谢紊乱的有效方法。根据这些结果,我们接下来研究了改善脓毒症MOF组织氧代谢的有效治疗方法。在严重脓毒症患者中,通过积极的液体复苏和儿茶酚胺给药进行血流动力学管理,以达到超正常的氧转运值。这些治疗在早期脓毒症中有效改善相对组织缺氧和预防器官功能障碍。然而,在极度发展的MOF患者中,这些治疗未能改善组织氧代谢,这应该主要是由于这些患者中各种体液介质影响的氧摄取减少。因此,虽然改善组织氧代谢的方法可能是脓毒症MOF的新治疗方法,但应建立另一种方法来改善O_2提取和血流动力学管理,以达到超正常的氧转运值。

项目成果

期刊论文数量(22)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Hirasawa H: "Recent advances in pathophysiologic and therapeutic considerations for septic multiple organ failure (SMOF)." Journal of Japanese Association for Acute Medicine. 5. 225-50 (1994)
Hirasawa H:“脓毒性多器官衰竭 (SMOF) 的病理生理学和治疗考虑的最新进展。”
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    0
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平澤 博之、他: "臓器血流、酸素拡散ならびに細胞代謝の制御" 集中治療. 7. 388-407 (1995)
Hiroyuki Hirasawa 等人:“器官血流、氧扩散和细胞代谢的控制”重症监护 7. 388-407 (1995)。
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    0
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Hirasawa H,et al: "Regulation of tissue perfusion, oxygen diffusion and cellular metabolism." Intensive and Critical Care Medicine. 7. 338-407 (1995)
Hirasawa H 等人:“组织灌注、氧扩散和细胞代谢的调节。”
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  • 影响因子:
    0
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中西加寿也、他: "胃粘膜内pHと酸素供給量係数、酸素消費量係数の比較検討" 集中治療. 7. 979-980 (1995)
Kazuya Nakanishi 等:“胃粘膜 pH、供氧系数和耗氧系数的比较研究”重症监护 7. 979-980 (1995)。
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  • 期刊:
  • 影响因子:
    0
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Nakanishi K,et al: "A comparison of gastric intramucosal pH with oxygen delivery and oxygen consumption." Intensive and Critical Care Medicine. 7. 979-80 (1995)
Nakanishi K 等人:“胃粘膜内 pH 值与氧输送和氧消耗的比较。”
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    0
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ODA Shigeto其他文献

ODA Shigeto的其他文献

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{{ truncateString('ODA Shigeto', 18)}}的其他基金

Possibility of treatment with erythropoietin for anemia in critically ill patients
促红细胞生成素治疗危重贫血的可能性
  • 批准号:
    15K15660
  • 财政年份:
    2015
  • 资助金额:
    $ 1.28万
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
Tailor-made medicine based on genetic polymorphism analyses in relation to biological and immunological responses
基于与生物和免疫反应相关的遗传多态性分析的定制药物
  • 批准号:
    22390335
  • 财政年份:
    2010
  • 资助金额:
    $ 1.28万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Order-made therapy based on analysis of genetic polymorphism related to cytokine production
基于细胞因子产生相关基因多态性分析的定制治疗
  • 批准号:
    19390457
  • 财政年份:
    2007
  • 资助金额:
    $ 1.28万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Tailor-made therapy for patients with septic multiple organ failure using a cytokine adsorbing column based on genetic analysis of cytokine related gene polymorphisms
基于细胞因子相关基因多态性遗传分析的细胞因子吸附柱为脓毒症多器官功能衰竭患者量身定制治疗
  • 批准号:
    16390514
  • 财政年份:
    2004
  • 资助金额:
    $ 1.28万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
DEVELOPMENT OF CYTOKINE ADSORPTION COLUMN AND THE TREATMENT OF MULTIPLE ORGAN FAILURE BY CYTOKINE ADSORPTION COLUMN
细胞因子吸附柱的研制及细胞因子吸附柱治疗多器官功能衰竭
  • 批准号:
    13671216
  • 财政年份:
    2001
  • 资助金额:
    $ 1.28万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Establishment of a new Severity Scoring System for the Patients with Multiple Organ Failure from the Aspect of Cellular Injury - Anoxic Necrosis and Apoptosis
从细胞损伤——缺氧坏死和凋亡角度建立多器官功能衰竭患者新的严重程度评分系统
  • 批准号:
    10671098
  • 财政年份:
    1998
  • 资助金额:
    $ 1.28万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)

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New general anesthesia strategies for oral and maxillofacial surgery based on maintenance of tissue oxygen metabolism
基于维持组织氧代谢的口腔颌面外科全身麻醉新策略
  • 批准号:
    19K10324
  • 财政年份:
    2019
  • 资助金额:
    $ 1.28万
  • 项目类别:
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Non-Invasive Study of Tissue Oxygen Metabolism Using Near Infrared laser Light ; Toward its Clinical Application
使用近红外激光对组织氧代谢进行非侵入性研究;
  • 批准号:
    01480337
  • 财政年份:
    1989
  • 资助金额:
    $ 1.28万
  • 项目类别:
    Grant-in-Aid for General Scientific Research (B)
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