Order-made therapy based on analysis of genetic polymorphism related to cytokine production

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It has been widely recognized that a degree of immuno-inflammatory response to insults, such as infection, trauma and surgery varies individually and the difference influences on morbidity and mortality in critically ill patients. The purpose of this study is to identify genetic polymorphisms of protein production related to immuno-inflammatory response, such as cytokines, and to establish order-made therapy based on genetic informations. In this study, we have developed a new DNA-chip which enables to analyze multiple single nucleotide polymorphisms (SNPs) easily and in a short period of time. Then, we first identified two cytokine related SNPs which significantly affect morbidity and mortality in critically ill ICU patients. These SNPs are unique in Japanese population compared to previously reported SNPs in Caucasian. The genetic information analyzed with this DNA-chip would be useful for more precise prediction of outcome in critically ill patients and is essential to establish future order-made therapy.