Basic research for the transmucosal pressure regulation in the middle ear cavity

中耳腔跨粘膜压力调节的基础研究

• 批准号: 06671739
• 负责人: TADA Naoki
• 金额: $ 1.34万
• 依托单位: KANSAI MEDICAL UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06671739/
• 关键词: gas exchange,; middle ear,; otitis media with effusion; 中耳腔圧調節; 経粘膜的換気; 酸素センサー; 中耳換気; 中耳腔粘膜

The purpose of this study was to develop a clinical examination for analyzes of the physiological function in the middle ear (ME).We studied a test to measure the transmucosal gas exchange capacity and compared normal ears and ears with otitis media with effusion (OME). ME cavity was insufflated with various gases with different compositions (room air, 100% nitrigen, 100% oxygen, mixed gas with 5% carbon dioxide and 95% oxygen). The ME pressure changes due to gas diffusion into or out of the mucosa were recorded by a pressure transducer and a recorder of oxygen partial pressure.Our study regarding middle ear ventilation mechanisms can be concluded as follows.1. Middle ear ventilation mechanisms in normal ears(1) The pressure absorption theory cannot account for middle ear ventilation mechanisms, under physiological conditions.(2) Transmucosal gas exchange is involved in pressure equilibration in the human middle ear cavity.2. Ventilatory disorders in otitis media with effusion (OME)(1) Transmucosal gas exchange capacity in cases of OME differs from that in normal ears.(2) Oxygen absorption seems to be elevated in case of OME.(3) Change in transmucosal pressure regulation may be involved in the pathogenesis of OME.

本研究旨在建立一种分析中耳生理功能的临床检查方法，通过对正常耳和分泌性中耳炎（OME）患者的跨粘膜气体交换能力的测定，比较正常耳和分泌性中耳炎（OME）患者的跨粘膜气体交换能力。ME腔内吹入不同成分的各种气体（室内空气、100%氮气、100%氧气、5%二氧化碳和95%氧气的混合气体）。通过压力传感器和氧分压记录仪记录由于气体扩散进入或流出粘膜引起的ME压力变化。我们对中耳通气机制的研究可以总结如下。正常人中耳通气机制的研究（1）压力吸收理论不能解释生理条件下中耳通气机制的变化。(2)中耳气体交换参与人中耳腔的压力平衡。渗出性中耳炎（OME）的通气障碍（1）渗出性中耳炎（OME）的跨粘膜气体交换能力与正常耳不同。(2)在OME的情况下，氧吸收似乎升高。(3)跨粘膜压力调节的改变可能参与了OME的发病机制。

项目成果

Kawasaki E: ANALYSIS OF GAS EXCHANGE IN MIDDLE EAR MUCOSA FOR THE INDICATIONS OF CHOLESTEATOMA SURGERY. CIC Edizioni Internazionali, Roma, Itary, 168-170 (1997)

川崎 E：中耳粘膜气体交换分析以了解胆脂瘤手术的适应症。

Kawasaki E: "CHOLESTEATOMA AND MASTOID SURGERY" edited by M.Sanna,MD(出版社,CIC Edizioni Internationali), 875 (1997)

川崎 E：“胆脂瘤和乳突手术”，M.Sanna, MD 编辑（出版商，CIC Edizioni Internationali），875 (1997)