Defining a new family of sodium channel accessory proteins

定义一个新的钠通道辅助蛋白家族

• 批准号: DP240102097
• 负责人: Prof Irina Vetter
• 金额: $ 42.62万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-25 至 2027-01-24
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP240102097
• 关键词: Defining; new; family; sodium; channel

Voltage-gated sodium channels are key proteins that function as multi-subunit complexes to regulate neuronal excitability. The project aims to investigate the structure and function of a novel family of accessory subunits by utilizing a class of toxins, derived from the giant Australian stinging tree, that directly binds to these proteins to modulate sodium channel function. The project aims to generate significant new knowledge on the function of sodium channels as multi-protein complexes. Expected outcomes of this project include development of novel channel-modulating molecules that may have applications as neuroscience tools to address fundamental questions about ion channel function and biology.

电压门控钠通道是关键蛋白质，可作为多生成复合物的功能来调节神经元兴奋性。该项目旨在通过利用从巨大的澳大利亚刺痛树中得出的一类毒素来研究新型辅助亚基的结构和功能，该毒素直接与这些蛋白质结合以调节钠通道功能。该项目旨在为钠通道作为多蛋白络合物的功能产生重要的新知识。该项目的预期结果包括开发新的通道调节分子，这些分子可能将其作为神经科学工具应用，以解决有关离子渠道功能和生物学的基本问题。