Defining a new family of sodium channel accessory proteins

定义一个新的钠通道辅助蛋白家族

• 批准号: DP240102097
• 负责人: Prof Irina Vetter
• 金额: $ 42.62万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-25 至 2027-01-24
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP240102097
• 关键词: Defining; new; family; sodium; channel

Voltage-gated sodium channels are key proteins that function as multi-subunit complexes to regulate neuronal excitability. The project aims to investigate the structure and function of a novel family of accessory subunits by utilizing a class of toxins, derived from the giant Australian stinging tree, that directly binds to these proteins to modulate sodium channel function. The project aims to generate significant new knowledge on the function of sodium channels as multi-protein complexes. Expected outcomes of this project include development of novel channel-modulating molecules that may have applications as neuroscience tools to address fundamental questions about ion channel function and biology.

电压门控钠通道是调节神经元兴奋性的多亚基复合物的关键蛋白。该项目旨在研究一类新的附属亚基家族的结构和功能，这些亚基来自澳大利亚巨型刺树，它直接结合这些蛋白质来调节钠通道功能。该项目旨在对钠通道作为多蛋白复合物的功能产生重要的新知识。该项目的预期成果包括开发新的通道调节分子，这些分子可能作为神经科学工具应用于解决有关离子通道功能和生物学的基本问题。