Using toxins to understand the mechanisms of pain

利用毒素来了解疼痛机制

• 批准号: FT130101215
• 负责人: Prof Irina Vetter
• 金额: $ 50.31万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-06 至 2017-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT130101215
• 关键词: Using; toxins; understand; mechanisms; pain

Toxins have evolved in plants, animals and microbes as part of defensive and/or prey capture strategies, and have proven to be invaluable research tools as well as providing leads for potential new therapies. This project will use subtype-selective toxins to define the role of ion channels in pain, using novel pathway-specific and disease-specific animal models of pain. The findings from this project will provide significant insight into the neuropharmacology of pain, will lead to the identification of novel molecular targets with analgesic potential and is expected to provide novel treatment approaches for pain.

毒素已经在植物、动物和微生物中进化，作为防御和/或猎物捕获策略的一部分，并已被证明是宝贵的研究工具，并为潜在的新疗法提供线索。该项目将使用亚型选择性毒素来定义离子通道在疼痛中的作用，使用新的途径特异性和疾病特异性疼痛动物模型。该项目的研究结果将为疼痛的神经药理学提供重要的见解，将导致具有镇痛潜力的新分子靶点的鉴定，并有望为疼痛提供新的治疗方法。