A humanised sensory neuron high-throughput screening platform

人性化感觉神经元高通量筛选平台

• 批准号: LP210100170
• 负责人: Prof Irina Vetter
• 金额: $ 11.69万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-06-10 至 2024-06-09
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP210100170
• 关键词: humanised; sensory; neuron; throughput; screening

Sensory neurons are responsible for converting external stimuli such as touch or temperature into graded electrical signals that allow us to interact with the world around us. However, unlike other cell types, sensory neurons cannot proliferate and thus must be removed from human cadavers, or animals, in order to study their pharmacology and function. This limits our ability to understand neuronal signalling pathways. This project aims to use sensory neurons derived from human stem cells to develop and optimise assays that can be used to study the pharmacology and function of human sensory neurons in vitro. This enhances access to critical model systems and technology platforms and removes the need for isolation of cells from cadavers.

感觉神经元负责将外部刺激（例如触摸或温度）转换为分级的电信号，从而使我们能够与周围的世界互动。但是，与其他细胞类型不同，感觉神经元不能扩散，因此必须从人尸体或动物中去除，以研究其药理学和功能。这限制了我们了解神经元信号通路的能力。该项目旨在使用从人类干细胞中得出的感觉神经元来开发和优化可用于研究人类感觉神经元在体外研究的药理学和功能的测定。这增强了对关键模型系统和技术平台的访问，并消除了从尸体中隔离细胞的需求。