Understanding the generation of hypothalamic sleep neurons

了解下丘脑睡眠神经元的生成

• 批准号: DP220100985
• 负责人: Prof Stefan Thor
• 金额: $ 39.85万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-01-21 至 2025-01-20
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP220100985
• 关键词: Understanding; generation; hypothalamic; sleep; neurons

This Project aims to investigate the mechanisms controlling the formation of the sleep neurons in the hypothalamus. We all sleep, and normal sleep-wake cycles play a central role in our biology. The functional role of these sleep neurons in the mature brain are well established. However, how the neurons are generated during development is very poorly defined. This project aims to address this critical knowledge gap, and will greatly increase our understanding of how the development of this critical aspect of organismal function is orchestrated during development. This project will also develop bioinformatics tools with broad utility within the biosciences field and enhance the capacity for interdisciplinary international collaborations.

该项目旨在研究控制下丘脑睡眠神经元形成的机制。我们都会睡觉，正常的睡眠-觉醒周期在我们的生物学中发挥着核心作用。这些睡眠神经元在成熟大脑中的功能作用已经明确。然而，神经元在发育过程中如何产生的定义非常不明确。该项目旨在解决这一关键的知识差距，并将极大地增进我们对在发育过程中如何协调有机体功能这一关键方面的发展的理解。该项目还将开发在生物科学领域具有广泛用途的生物信息学工具，并增强跨学科国际合作的能力。