Mapping networks governing cell state plasticity: how, where and when?

绘制控制细胞状态可塑性的网络：如何、何地和何时？

• 批准号: DP220104036
• 负责人: A/Prof Christine Chaffer
• 金额: $ 43.96万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-01-01 至 2024-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP220104036
• 关键词: Mapping; networks; governing; cell; state

Single cell organisms are the basic unit of life, yet, if they had not developed the ability to change cell states we would not exist today. Changing cell states lies at the core of almost every developmental and disease process in multicellular organisms. Building upon our fundamental discovery that stem cells and non-stem cells readily interconvert, we will now incorporate innovative cell systems and the development of our new multi-layered systems biology strategy to elucidate the first comprehensive understanding of the cell biology that underlies cell state changes. These studies are a major step toward understanding the fundamentals of life.

单细胞生物是生命的基本单位，然而，如果它们没有发展出改变细胞状态的能力，我们今天就不会存在。改变细胞状态是多细胞生物体中几乎所有发育和疾病过程的核心。基于我们的基本发现，即干细胞和非干细胞容易相互转化，我们现在将结合创新的细胞系统和我们新的多层系统生物学策略的发展，以阐明细胞生物学的第一个全面理解，细胞状态的变化。这些研究是理解生命基本原理的重要一步。