Role of vanadium in endemic diseases in Northeast Thailand

钒在泰国东北部地方病中的作用

基本信息

批准号：
07041167
负责人：
ENDOU Hitoshi
金额：
$ 5.25万
依托单位：
Kyorin University School of Medicine
依托单位国家：
日本
项目类别：
Grant-in-Aid for international Scientific Research
财政年份：
1995
资助国家：
日本
起止时间：
1995 至 1996
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07041167/
关键词：
Distal renal tubular acidosis urinary stone hypo-kelamic periodic paralysis urinary vanadium trace element sodium pump animal model environmental substance (water, soil)遠位尿細管性酸血症麻痺低カリウム性周期性四肢低カリウム性酸血症麻痺

项目摘要

In order to identify possible causes of sudden unexplained death syndrome (SUDS) -related endemic diseases (including distal renal tubular acidosis, hypokalemic periodic paralysis and urinary stone) in North-East Thailand, a fieldwork and laboratory investigations were carried out.1. FieldworkWe visited villagers in Yasothorn district whose members were suffered from SUDS,and made interviews. As analytical samples, their blood, urine, water and soil were collected for the determination of various elements including Vanadate (V).1) Genetic factorsSince the local definition of SUDS is different from clinical one, it was difficult to identify a possibility of genetic diathesis. Nevertheless, blood and urine samples were collected from a limited number of SUDS-relatives for further analysis of DNA to look for abnormal genes in familiar QT elongation syndrome.2) Acquired factorsWe analyzed 43 different elements in the collected samples from North-East (NE) and Bangkok (BK) as controls. Vanadium contents in soils and water revealed no difference between NE and BK,whereas contents of Ca, Mg, K and Pb in soil were higher in BK than NE.Only Na in NE was higher than NE.V contents in plasma and urine in NE villagers were higher than BK.These results suggest that even under low plasma K in NE villagers their intracellular K could be maintained at relatively high levels, and that one of causes of the endemic diseases may be disturbance of this K-retaining mechanism.2. Animal model experimentsThe treatment of rats with low potassium diet for longer time than 1 month cased hypo-potassemia, and revealed abnormality in cardiac and renal functions. Since no SUDS occurred under the hypo K,additional factors e.g.low Mg should be investigated.

为了确定在泰国东北部的突然无法解释的死亡综合征（SUD）相关的流行疾病（包括远端肾小管酸中毒，低钾血症周期性瘫痪和尿石）的原因，进行了野外研究和实验室研究。1。 FieldWorkwe访问了Yasothorn地区的村民，其成员患有SUDS，并进行了采访。作为分析样本，收集了血液，尿液，水和土壤，以确定包括钒酸盐（v）.1）遗传因素的各种元素，这些遗传因素与临床上的局部定义不同，很难识别出遗传临床的可能性。然而，从有限数量的SUDS依赖性中收集了血液和尿液样品，以进一步分析DNA，以寻找熟悉的QT延长延长综合征中的异常基因。2）获取因子我们分析了来自东北（NE）和Bangkok（NE）和Bangkok（BK）收集的样品中的43个不同的元素。土壤和水中的气谷含量揭示了NE和BK之间没有差异，而Ca，Mg，K和Pb的含量高于NE的NE. NE的土壤高于NE.V的NE.V含量高于NE.V的NE.V含量，而NE村民中的NE.V含量高于bk的含量高于bk。这些结果在较低的neage and Atagiand at Atacma aTaCma aTACLASM aTACLASM aTACLASS MOLTACTAINS aCTACTAR中的较低的较低的较低的弱点较高的等离子较高的弱点K。特有疾病可能是对这种k的机制的干扰2。动物模型实验低钾饮食对大鼠的治疗时间长于1个月的低毒性血症，并揭示心脏和肾功能异常。由于在hypo k下没有发生SUD，因此应研究其他因素。