HTLV-infection and diseases in South America and Caribbean

南美洲和加勒比地区的 HTLV 感染和疾病

基本信息

批准号：
07042007
负责人：
SONODA Shunro
金额：
$ 7.62万
依托单位：
Kagoshima University
依托单位国家：
日本
项目类别：
Grant-in-Aid for international Scientific Research
财政年份：
1995
资助国家：
日本
起止时间：
1995 至 1997
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07042007/
关键词：
HTLV-I HLA Andes Natives of South American Easter Island HAM TSP ATL disease susceptibility ethnoeoidemiology II アンデス先住民ジャマイカ黒人 HLAハプロタイプ疾病感受性モンゴロイド

项目摘要

In order to elucidate the susceptibility to HTLV-I/II infection and diseases, we investigated HTLV-I and II infection foci amang South American and Caribbean populations. In this study, we have collected blood samples from the Andes native populations of Bolivia, Peru, Colombia, Chile and Argentina, the Orinoco low-land population of Colombia and Venezuela, and the Patagonia low-land population of Chile, as well as Black population of Jamaica, Colombia and Brazil, under informed consent.HTLV-I foci were found among the Andes native populations of Bolivia, Peru, colombia, chile and Argentina. On the otherhand, HTLV-II foci were identified among the Orinoco low-land population of Colombia and Venezuela, and the Patagonia low-land population of Chile. Thus, the distribution of HTLV-I and HTLV-II foci are geographically sagregated each other. HLA background of HTLV-I carriers of the South American natives showed common HLA class I and II alleles of HTLV-I carriers of Southern Japanese and ethno-specific HLA alleles.We investigated HTLV-I immunoepitopes recognized by the HLA alleles at risk for ATL and HAM/TSP.Thus, HLA class I A26^<**>, B^<**>4002/6 were at risk for ATL and rhese HLA alleles lacked anchor motifs in HTLV-I Tax peptides. While HLA class I A24, B^<**>07 were at risk for HAM/TSP and these HLA alleles showed many anchor motifs in HTLV-I Tax peptides.The blood samples collected in this study have been consisted of live lymphocytes bank and plasma bank, which are available for seroepidemiolgical examination and immunogenetical analysis.

为了阐明对HTLV-I/II感染和疾病的敏感性，我们研究了HTLV-I和II感染焦点焦点南美洲和加勒比海人群。在这项研究中，我们收集了来自玻利维亚，秘鲁，哥伦比亚，智利和阿根廷的安第斯山脉本地人口的血液样本，哥伦比亚和委内瑞拉的Orinoco低地人口，委内瑞拉的低地人口，以及巴塔哥尼亚低地的辣椒种群，以及在牙买加，哥伦比亚和巴西的黑人人口中，与本地人相同。秘鲁，哥伦比亚，智利和阿根廷。另一方面，在哥伦比亚和委内瑞拉的Orinoco低地人口中，发现了HTLV-II灶，以及智利的巴塔哥尼亚低地人口。因此，HTLV-I和HTLV-II焦点的分布在地理上彼此分散。南美人的HTLV-I载体的HLA背景表明，HTLV-I载体的HLA I和II类等位基因很常见，日本和民族特异性的HLA等位基因。 B^<**> 4002/6有ATL的风险，Rhese HLA等位基因在HTLV-I税收肽中缺乏锚定图案。 While HLA class I A24, B^<**>07 were at risk for HAM/TSP and these HLA alleles showed many anchor motifs in HTLV-I Tax peptides.The blood samples collected in this study have been consisted of live lymphocytes bank and plasma bank, which are available for seroepidemiolgical examination and immunogenetical analysis.