Modulatory mechanisms of cardiac ion channels.

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The collaboration with Professor H.A.Fozzard has made a great advance in the technical achievements of the expressed channels functions and structural confirmation. We also acquired the clones of ATP-sensitive K^+ channel. Now, we are ready to express these K^+ channels and functional modulation of HERG K channel by tyrosin phosphorylation is under investigation. Furthermore, mutation of HERG K^+ channels is one of etiological factors for long QT syndrome. Therefore, we started to examine functional abnormality of the mutated channels. The joint research with Professor H.C.Hartzell has made a great advance for the purification of ryanodine receptor channel proteins, which enables us to study their function with much higher success rate. Modulation of Ca^<2+> -activated Cl^- -channel and L-type Ca^<2+> channel by protein phosphorylation and phosphatases is now studied with refined technique and new information owing to the fruits of this joint research.