Studies on the differention and activation mechanisms of T cell vi lymphocye functioning antigen (LFA).

T细胞vi淋巴细胞功能抗原（LFA）分化及激活机制的研究。

• 批准号: 07407068
• 负责人: OKUMURA Ko
• 金额: $ 6.14万
• 依托单位: Juntendo University School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07407068/
• 关键词: LFA; TNF; TNF-R; monoclonal antibody; anergy; FasL; パ-フォリン; ジーンターゲッティン; CD80,CD86; TNF; TNF-R; CD27; GVHD; CD95L; CD80; CD86; 寛容; Th1; Th2; CTLA-4; アナジー; エイズ

We have been studied the biological significance of cell to cell interactions depending on various lymphocyte factioning molecules belonging to Ig-super family molecules and/or TNF/TNF-R family molecules. Especially utilizing monoclonal antibodies to various LFA molecules involved in the initiation of immune response, we found that the some LFA are extremely associated to the T cell activation as well as T cell anergy.Regarding to the molecules involved in effector phase of immune response, we found that TNF/TNF-R interaction is fully involved in the immunological disorders. Addition, our original monoclonal antibodies against such molecules are now widely used in many labs.

我们已经研究了依赖于属于Ig-超家族分子和/或TNF/TNF-R家族分子的各种淋巴细胞分配分子的细胞与细胞相互作用的生物学意义。特别是利用针对参与免疫应答启动的各种LFA分子的单克隆抗体，我们发现某些LFA与T细胞活化和T细胞无能密切相关，而对于参与免疫应答效应期的分子，我们发现TNF/TNF-R相互作用充分参与了免疫紊乱。此外，我们最初针对这些分子的单克隆抗体现在被广泛用于许多实验室。

项目成果

Maeda,K.,et al.: "Characterization of rat CD80 and CD86 by molecular cloning and mAb." Int.Immunol.9. 993-1000 (1997)

Maeda,K.,et al.：“通过分子克隆和 mAb 表征大鼠 CD80 和 CD86。”

Kawamura, T., et al.: "Critical role of NK1^+ T cells in IL-12-induced immune resposes in vivo." J.Immunol.160. 16-19 (1998)

Kawamura, T. 等人：“NK1^ T 细胞在 IL-12 诱导的体内免疫反应中的关键作用。”

Bashuda,H.,et al.: "Induction of persistent allograft tolerance in the rat by combined treatment with anti-LFA-1 and anti-ICAM-1 monoclonal antibodies,donor specific transfusion,and FK506." Transplantation. 6. 117-122 (1996)

Bashuda, H. 等人：“通过抗 LFA-1 和抗 ICAM-1 单克隆抗体、供体特异性输血和 FK506 联合治疗，诱导大鼠持续同种异体移植耐受。”

Takazawa, K., et al.: "Synergistic effects of mycophenolate Mofetil (MMF, RS-61443) and anti-LFA-1 / monoclonal antibodies on the prolongation of heart allograft survival in rats." Transplantation. 28. 1980-1981 (1996)

Takazawa, K. 等人：“吗替麦考酚酯（MMF，RS-61443）和抗 LFA-1/单克隆抗体对延长大鼠同种异体心脏移植物存活的协同作用。”

Kaneko,Y.et al: "CD40-mediated stimulation of B1 and B2 cells:implication in autoantibody production in murine lupus." Eur.J.Immunol.26. 3061-3065 (1996)

Kaneko,Y.et al：“CD40 介导的 B1 和 B2 细胞刺激：对小鼠狼疮自身抗体产生的影响。”